Structure of PDB 7xti Chain A Binding Site BS02

Receptor Information
>7xti Chain A (length=1404) Species: 460519 (Komagataella phaffii) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
SQFPYSSAPLRSVKEVQFGLLSPEEIRAISVVKIEYPEIMDESRQRPREG
GLNDPKLGSIDRNFKCQTCGEGMAECPGHFGHMELAKPVFHIGFIPKIKK
VCECICMNCGKLLLDETNPTMAQAIRIRDPKKRFNAVWQLCKTKMVCEAD
APVSRGGCGNTQPVVRKDGMKLWGTWKKSRDAQPERKLLTPGEILNVFKH
ISPEDCFRLGFNEDYARPEWMIITVLPVPPPQVRPSIAMDETTQGQDDLT
HKLSDILKANINVQKLEMDGSPQHIINEVEQLLQFHVATYMDNDIAGQPQ
ALQKSGRPVKAIRARLKGKEGRLRGNLMGKRVDFSARTVISGDPNLELDQ
VGVPISIAKTLSYPETVTQYNIHRLTEYVRNGPNEHPGAKYVIRDNGDRI
DLRYHKRAGDIVLQYGWKVERHLMDDDPVLFNRQPSLHKMSMMAHRVKVM
PYSTFRLNLSVTSPYNADFDGDEMNLHVPQSEETRAELSQLCAVPLQIVS
PQSNKPVMGIVQDTLCGVRKMTLRDTFIEYEQVMNMLFWVPSWDGVVPQP
AILKPKPLWTGKQLLSIAIPSGIHLQRTDGGNSLLSPKDNGMLIVDGKVM
FGVVDKKTVGSGGGGLIHTVMREKGPKICAELFGNIQKVVNYWLLHNGFS
IGIGDAIADASTMKEITHAISSAKEQVQEIIYKAQHNELELKPGMTLRES
FEGEVSRTLNDARDSAGRSAEMNLKDLNNVKQMVSAGSKGSFINIAQMSA
CVGQQMVEGKRIAFGFADRSLPHFTKDDFSPESKGFVENSYLRGLTPQEF
FFHAMAGREGLIDTAVKTAETGYIQRRLVKALEDIMVHYDGTTRNSLGDI
IQFLYGEDGLDGTQVERQTIDTIPGSDKAFHKRYYVDLMDEKNSIKPDVI
EYAADILGDVELQKELNSEYEQLVSDRKFLREIVFVNGDHNWPLPVNLRR
IIQNAQQIFHLDRAKASDLTIPEIIHGVRDLCKKLFVLRGENELIKEAQQ
NATSLFQCLVRARLATRRILEEFRLNRDAFEWVLGTIEAQFQRSLVHPGE
MVGVIAAQSIGEPATQMNVTLGVPRLKEILNVAKNIKTPALTVYLDREIA
LDIEKAKVIQSSIEYTTLKNVTSATEIYYDPDPTSTVIEEDFDTVEAYFS
QSPWLLRLELDRARMLDKQLTMNQVADKISEVFSDDLFVMWSEDNADKLI
IRCRVIEEDQMLKRIEAHMLDLIALRGIPGISKVYMVKHKVSVPDESGEY
KNEELWALETDGINLAEVMAVPGVDSSRTYSNSFVEILSVLGIEATRSSL
YKEILNVIAFDGSYVNYRHMALLVDVMTSRGYLMAITRHGINRADTGALM
RCSFEETVEILFEAGAAAELDDCRGVSENVMLGQLAPMGTGAFDVMIDEK
LLTS
Ligand information
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

[Spin on] [Spin off] [Reset]
[High quality] [Low quality]
[White background] [Black background]
[Spin on] [Spin off] [Reset]
[High quality] [Low quality]
[White background] [Black background]
PDB7xti Structural basis of nucleosome disassembly and reassembly by RNAPII elongation complex with FACT.
Resolution3.9 Å
Binding residue
(original residue number in PDB)		R63 I251 Y418 D484 D486
Binding residue
(residue number reindexed from 1)		R62 I237 Y404 D470 D472
Enzymatic activity
Enzyme Commision number 2.7.7.6: DNA-directed RNA polymerase.
Gene Ontology
Molecular Function
GO:0001055 RNA polymerase II activity
GO:0003677 DNA binding
GO:0003899 DNA-directed 5'-3' RNA polymerase activity
GO:0016779 nucleotidyltransferase activity
GO:0034062 5'-3' RNA polymerase activity
GO:0046872 metal ion binding
Biological Process
GO:0006351 DNA-templated transcription
GO:0006366 transcription by RNA polymerase II
Cellular Component
GO:0000428 DNA-directed RNA polymerase complex
GO:0005634 nucleus
GO:0005665 RNA polymerase II, core complex

View graph for
Molecular Function
View graph for
Biological Process
View graph for
Cellular Component
External links
PDB RCSB:7xti, PDBe:7xti, PDBj:7xti
PDBsum7xti
PubMed35981082
UniProtC4R4Y0

[Back to BioLiP]