Structure of PDB 7xib Chain A Binding Site BS02

Receptor Information
>7xib Chain A (length=815) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
GPTKATTTKLVYQIFDTFFAEQIELEVGDCVSVIPLYLARVTALWEDSSN
GQMFHAHWFCAGTDTVLGATSDPLELFLVDECEDMQLSYIHSKVKVIYKA
PSENWAMEGGMGKTYFYQLWYDQDYARFESPPKTQPKFCVSCARLAEMRQ
KEIPRVLEQLEDLDSRVLYYSATKNGILYRVGDGVYLPPEAFTFNIKLPV
DEDLYPEHYRKYSDYIKGSNLDAPEPYRIGRIKEIFCPKKSNGRPNETDI
KIRVNKFYRPENTHKSTPASYHADINLLYWSDEEAVVDFKAVQGRCTVEY
GEDLPECVQVYSMGGPNRFYFLEAYNAKSKSFEDPPNHARSLPKLRTLDV
FSGCGGLSEGFHQAGISDTLWAIEMWDPAAQAFRLNNPGSTVFTEDCNIL
LKLVMAGETTNSRGQRLPQKGDVEMLCGGPPCQGFSGMNRFNSRTYSKFK
NSLVVSFLSYCDYYRPRFFLLENVRNFVSFKRSMVLKLTLRCLVRMGYQC
TFGVLQAGQYGVAQTRRRAIILAAAPGEKLPLFPEPLHVFAPRACQLSVV
VDDKKFVSNITRLSSGPFRTITVRDTMSDLPEVRNGASALEISYNGEPQS
WFQRQLRGAQYQPILRDHICKDMSALVAARMRHIPLAPGSDWRDLPNIEV
RLSDGTMARKLRYTHHDRKNGRSSSGALRGVCSCVEAGKACDPAARQFNT
LIPWCLPHTGNRHNHWAGLYGRLEWDGFFSTTVTNPEPMGKQGRVLHPEQ
HRVVSVRECARSQGFPDTYRLFGNILDKHRQVGNAVPPPLAKAIGLEIKL
CMLAKARESASAKIK
Ligand information
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

[Spin on] [Spin off] [Reset]
[High quality] [Low quality]
[White background] [Black background]
[Spin on] [Spin off] [Reset]
[High quality] [Low quality]
[White background] [Black background]
PDB7xib Structural basis for activation of DNMT1.
Resolution2.23 Å
Binding residue
(original residue number in PDB)		S977 Y979 K981 P1224 P1225 C1226 Q1227 S1230 M1232 N1233 F1235 Y1240 E1266 R1312 R1337 N1508 T1525 T1528 G1534 K1535 N1578
Binding residue
(residue number reindexed from 1)		S213 Y215 K217 P430 P431 C432 Q433 S436 M438 N439 F441 Y446 E472 R518 R543 N714 T731 T734 G740 K741 N784
Enzymatic activity
Enzyme Commision number 2.1.1.37: DNA (cytosine-5-)-methyltransferase.
Gene Ontology
Molecular Function
GO:0003677 DNA binding
GO:0003682 chromatin binding
GO:0003886 DNA (cytosine-5-)-methyltransferase activity
GO:0008168 methyltransferase activity
GO:0008270 zinc ion binding
Biological Process
GO:0006346 DNA methylation-dependent heterochromatin formation
Cellular Component
GO:0005634 nucleus

View graph for
Molecular Function
View graph for
Biological Process
View graph for
Cellular Component
External links
PDB RCSB:7xib, PDBe:7xib, PDBj:7xib
PDBsum7xib
PubMed36414620
UniProtP26358|DNMT1_HUMAN DNA (cytosine-5)-methyltransferase 1 (Gene Name=DNMT1)

[Back to BioLiP]