Structure of PDB 7xez Chain A Binding Site BS02

Receptor Information
>7xez Chain A (length=163) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
SGGRATQSPGDSRRLSIQRAIQSLVHAAQCRNANCSLPSCQKMKRVVQHT
KGCKRKTNGGCPICKQLIALAAYHAKHCQENKCPVPFCLNIKQKGSGGSG
GSGGSGGSGGSSQKVFVSKVEAVIHPQFLADLLSPEKQRDPLALIEELEQ
EEGLTLAQLVQKR
Ligand information
Ligand IDZN
InChIInChI=1S/Zn/q+2
InChIKeyPTFCDOFLOPIGGS-UHFFFAOYSA-N
SMILES
SoftwareSMILES
CACTVS 3.341[Zn++]
ACDLabs 10.04
OpenEye OEToolkits 1.5.0		[Zn+2]
FormulaZn
NameZINC ION
ChEMBLCHEMBL1236970
DrugBankDB14532
ZINC
PDB chain7xez Chain A Residue 502 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

[Spin on] [Spin off] [Reset]
[High quality] [Low quality]
[White background] [Black background]
[Spin on] [Spin off] [Reset]
[High quality] [Low quality]
[White background] [Black background]
PDB7xez Structural Mechanism of BRD4-NUT Fusion Protein in p300-Activated Hyperacetylation
ResolutionN/A
Binding residue
(original residue number in PDB)		H26 C30 C35 C40
Binding residue
(residue number reindexed from 1)		H26 C30 C35 C40
Annotation score1
Enzymatic activity
Enzyme Commision number 2.3.1.-
2.3.1.48: histone acetyltransferase.
Gene Ontology
Molecular Function
GO:0004402 histone acetyltransferase activity
Biological Process
GO:0006355 regulation of DNA-templated transcription

View graph for
Molecular Function
View graph for
Biological Process
External links
PDB RCSB:7xez, PDBe:7xez, PDBj:7xez
PDBsum7xez
PubMed
UniProtQ09472|EP300_HUMAN Histone acetyltransferase p300 (Gene Name=EP300);
Q86Y26

[Back to BioLiP]