Structure of PDB 7xd0 Chain A Binding Site BS02

Receptor Information
>7xd0 Chain A (length=99) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
KPHRYRPGTVALREIRRYQKSTELLIRKLPFQRLVREIAQDFKTDLRFQS
SAVMALQEASEAYLVALFEDTNLCAIHAKRVTIMPKDIQLARRIRGERA
Ligand information
>7xd0 Chain J (length=146) [Search DNA sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
atcggatgtatatatctgacacgtgcctggagactagggagtaatcccct
tggcggttaaaacgcgggggacagcgcgtacgtgcgtttaagcggtgcta
gagctgtctacgaccaattgagcggcctcggcaccgggattctcga
Receptor-Ligand Complex Structure
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PDB7xd0 H2B Lys34 Ubiquitination Induces Nucleosome Distortion to Stimulate Dot1L Activity.
Resolution3.48 Å
Binding residue
(original residue number in PDB)		Y41 R42 T45 R72 R83 Q85 V117 T118 M120
Binding residue
(residue number reindexed from 1)		Y5 R6 T9 R36 R47 Q49 V81 T82 M84
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0003677 DNA binding
GO:0030527 structural constituent of chromatin
GO:0046982 protein heterodimerization activity
Cellular Component
GO:0000786 nucleosome

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Molecular Function
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Cellular Component
External links
PDB RCSB:7xd0, PDBe:7xd0, PDBj:7xd0
PDBsum7xd0
PubMed35739357
UniProtQ71DI3|H32_HUMAN Histone H3.2 (Gene Name=H3C15)

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