Structure of PDB 7x3p Chain A Binding Site BS02
Receptor Information
>7x3p Chain A (length=267) Species:
9606
(Homo sapiens) [
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PSSSMADFRKFFAKAKHIVIISGAGVSAESGVPTFRGAGGYWRKWQAQDL
ATPLAFAHNPSRVWEFYHYRREVMGSKEPNAGHRAIAECETRLGKQGRRV
VVITQNIDELHRKAGTKNLLEIHGSLFKTRCTSCGVVAENYKSPICPALS
GKGAPEPGTQDASIPVEKLPRCEEAGCGGLLRPHVVWFGENLDPAILEEV
DRELAHCDLCLVVGTSSVVYPAAMFAPQVAARGVPVAEFNTETTPATNRF
RFHFQGPCGTTLPEALA
Ligand information
Ligand ID
ZN
InChI
InChI=1S/Zn/q+2
InChIKey
PTFCDOFLOPIGGS-UHFFFAOYSA-N
SMILES
Software
SMILES
CACTVS 3.341
[Zn++]
ACDLabs 10.04
OpenEye OEToolkits 1.5.0
[Zn+2]
Formula
Zn
Name
ZINC ION
ChEMBL
CHEMBL1236970
DrugBank
DB14532
ZINC
PDB chain
7x3p Chain A Residue 403 [
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Receptor-Ligand Complex Structure
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PDB
7x3p
Crystal structure of human SIRT5 in complex with diazirine inhibitor 9
Resolution
1.56 Å
Binding residue
(original residue number in PDB)
C166 C169 C207 C212
Binding residue
(residue number reindexed from 1)
C131 C134 C172 C177
Annotation score
1
Enzymatic activity
Enzyme Commision number
2.3.1.-
Gene Ontology
Molecular Function
GO:0036054
protein-malonyllysine demalonylase activity
GO:0036055
protein-succinyllysine desuccinylase activity
GO:0070403
NAD+ binding
View graph for
Molecular Function
External links
PDB
RCSB:7x3p
,
PDBe:7x3p
,
PDBj:7x3p
PDBsum
7x3p
PubMed
UniProt
Q9NXA8
|SIR5_HUMAN NAD-dependent protein deacylase sirtuin-5, mitochondrial (Gene Name=SIRT5)
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