Structure of PDB 7x22 Chain A Binding Site BS02

Receptor Information
>7x22 Chain A (length=986) Species: 10116 (Rattus norvegicus) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
GMDLDDHRLSNTELEQKYGTNIIQGLSSVRATELLARDGPNTLTPPKQTP
EIIKFLKQMVGGFSILLWIGAALCWIAFVIQYVNNSASLDNVYLGAILVL
VVILTGIFAYYQEAKSTNIMASFSKMIPQQALVIRDAEKKVISAEQLVVG
DVVEIKGGDQIPADIRLVFSQGCKVDNSSLTGESEPQARSTEFTHENPLE
TKNIGFYSTTCLEGTATGIVINTGDRTIIGRIASLASGVGSEKTPIAIEI
EHFVHIVAGVAVSIGIIFFITAVCMKYYVLDAIIFLISIIVANVPEGLLA
TVTVTLSLTAKRMAKKNCLVKNLEAVETLGSTSIICSDKTGTLTQNRMTV
AHLWFDNQIFVADTSENQTKQAFDQSSGTWASLSKIITLCNRAEFRPGQE
SVPIMKRTVVGDASETALLKFSEVILGDVMGIRKRNHKVAEIPFNSTNKF
QLSIHETEDPNNKRFLVVMKGAPERILEKCSTIMINGQEQPLDKSSADSF
HTAYMELGGLGERVLGFCHLYLPAEQFPQSYIFDVDSVNFPTSNFCFVGL
LSMIDPPRSTVPDAVSKCRSAGIKVIMVTGDHPITAKAIAKSVGIISANN
ETVEDIAKRRNIAVEQVNKREAKAAVVTGMELKDMTPEQLDELLTNYQEI
VFARTSPQQKLIIVEGCQRQDAIVAVTGDGVNDSPALKKADIGIAMGIAG
SDAAKNAADMVLLDDNFASIVTGVEEGRLIFDNLKKTIAYTLTSNIAELC
PFLIYIVAGLPLPIGTITILFIDLGTDIIPSIALAYEKAESDIMNRKPRH
KKKDRLVNTQLAIYSYLHIGLMQALGGFLVYFTVYAQQGFWPTSLINLRV
AWETDDINDLEDSYGQEWTRYQRKYLEWTGSTAFFVAIMIQQIADLIIRK
TRRNSIFQQGLFRNKVIWVGIASQVIVALILSYGLGSVPALSFTMLRVQY
WFVAVPHAILIWVYDEMRKLFIRLYPGSWWDKNMYY
Ligand information
Ligand IDMG
InChIInChI=1S/Mg/q+2
InChIKeyJLVVSXFLKOJNIY-UHFFFAOYSA-N
SMILES
SoftwareSMILES
ACDLabs 10.04
OpenEye OEToolkits 1.5.0		[Mg+2]
CACTVS 3.341[Mg++]
FormulaMg
NameMAGNESIUM ION
ChEMBL
DrugBankDB01378
ZINC
PDB chain7x22 Chain A Residue 1102 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
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PDB7x22 Structure and function of H + /K + pump mutants reveal Na + /K + pump mechanisms.
Resolution3.0 Å
Binding residue
(original residue number in PDB)		D388 T390 D729
Binding residue
(residue number reindexed from 1)		D338 T340 D679
Annotation score1
Enzymatic activity
Enzyme Commision number 7.2.2.13: Na(+)/K(+)-exchanging ATPase.
7.2.2.19: H(+)/K(+)-exchanging ATPase.
Gene Ontology
Molecular Function
GO:0000166 nucleotide binding
GO:0005215 transporter activity
GO:0005391 P-type sodium:potassium-exchanging transporter activity
GO:0005515 protein binding
GO:0005524 ATP binding
GO:0008556 P-type potassium transmembrane transporter activity
GO:0008900 P-type potassium:proton transporter activity
GO:0016887 ATP hydrolysis activity
GO:0046872 metal ion binding
Biological Process
GO:0006813 potassium ion transport
GO:0006814 sodium ion transport
GO:0006883 intracellular sodium ion homeostasis
GO:0006885 regulation of pH
GO:0010038 response to metal ion
GO:0010248 establishment or maintenance of transmembrane electrochemical gradient
GO:0014070 response to organic cyclic compound
GO:0030007 intracellular potassium ion homeostasis
GO:0036376 sodium ion export across plasma membrane
GO:0055075 potassium ion homeostasis
GO:1902600 proton transmembrane transport
GO:1990573 potassium ion import across plasma membrane
Cellular Component
GO:0005886 plasma membrane
GO:0016020 membrane
GO:0016323 basolateral plasma membrane
GO:0016324 apical plasma membrane

View graph for
Molecular Function
View graph for
Biological Process
View graph for
Cellular Component
External links
PDB RCSB:7x22, PDBe:7x22, PDBj:7x22
PDBsum7x22
PubMed36085139
UniProtP54708|AT12A_RAT Potassium-transporting ATPase alpha chain 2 (Gene Name=Atp12a)

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