Structure of PDB 7wwt Chain A Binding Site BS02

Receptor Information

>7wwt Chain A (length=153) Species: 9615 (Canis lupus familiaris)

MEMKAVCVLKGQGPVEGTIHFVQKGSGPVVVSGTITGLTEGEHGFHVHQF
GDNTQGCTSAGPHFNPLSKKHGGPKDQERHVGDLGNVTAGKDGVAIVSIE
DSLIALSGDYSIIGRTMVVHEKRDDLGKGDNEESTQTGNAGSRLACGVIG
IAQ

Ligand information

• Ligand ID: CU
• InChI: InChI=1S/Cu/q+2
• InChIKey: JPVYNHNXODAKFH-UHFFFAOYSA-N
• SMILES:
  ACDLabs 10.04
  OpenEye OEToolkits 1.5.0: [Cu+2]
  CACTVS 3.341: [Cu++]
• Formula: Cu
• Name: COPPER (II) ION
• DrugBank: DB14552
• PDB chain: 7wwt Chain A Residue 202

Receptor-Ligand Complex Structure

Structure summary

• PDB: 7wwt Intrinsic structural vulnerability in the hydrophobic core induces species-specific aggregation of canine SOD1 with degenerative myelopathy-linked E40K mutation.
• Resolution: 1.6 Å
• Binding residue (original residue number in PDB): H46 H48 H63 H120
• Binding residue (residue number reindexed from 1): H46 H48 H63 H120
• Annotation score: 1

Enzymatic activity

• Enzyme Commision number: 1.15.1.1: superoxide dismutase.

Gene Ontology

Molecular Function

• GO:0004784 superoxide dismutase activity
• GO:0005507 copper ion binding
• GO:0016209 antioxidant activity
• GO:0016491 oxidoreductase activity
• GO:0046872 metal ion binding

Biological Process

• GO:0006801 superoxide metabolic process
• GO:0019430 removal of superoxide radicals
• GO:0072593 reactive oxygen species metabolic process

Cellular Component

• GO:0005634 nucleus
• GO:0005737 cytoplasm
• GO:0005739 mitochondrion
• GO:0005777 peroxisome
• GO:0005829 cytosol

External links

• PDB: RCSB:7wwt, PDBe:7wwt, PDBj:7wwt
• PDBsum: 7wwt
• PubMed: 37156398
• UniProt: Q8WNN6|SODC_CANLF Superoxide dismutase [Cu-Zn] (Gene Name=SOD1)