Structure of PDB 7wn8 Chain A Binding Site BS02

Receptor Information
>7wn8 Chain A (length=116) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
QLLFNKTKSVEFTFCNDTVVIPCFVTNMEAQNTTEVYVKWKFKGRDIYTF
DGALNKSTVPTDFSSAKIEVSQLLKGDASLKMDKSDAVSHTGNYTCEVTE
LTREGETIIELKYRVV
Ligand information
Ligand IDZN
InChIInChI=1S/Zn/q+2
InChIKeyPTFCDOFLOPIGGS-UHFFFAOYSA-N
SMILES
SoftwareSMILES
CACTVS 3.341[Zn++]
ACDLabs 10.04
OpenEye OEToolkits 1.5.0		[Zn+2]
FormulaZn
NameZINC ION
ChEMBLCHEMBL1236970
DrugBankDB14532
ZINC
PDB chain7wn8 Chain A Residue 403 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
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PDB7wn8 A pH-dependent anti-CD47 antibody that selectively targets solid tumors and improves therapeutic efficacy and safety.
Resolution2.8 Å
Binding residue
(original residue number in PDB)		D80 H108
Binding residue
(residue number reindexed from 1)		D62 H90
Annotation score4
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0070053 thrombospondin receptor activity
Biological Process
GO:0022409 positive regulation of cell-cell adhesion
GO:0050729 positive regulation of inflammatory response
GO:0050766 positive regulation of phagocytosis
Cellular Component
GO:0005886 plasma membrane

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:7wn8, PDBe:7wn8, PDBj:7wn8
PDBsum7wn8
PubMed36650558
UniProtQ08722|CD47_HUMAN Leukocyte surface antigen CD47 (Gene Name=CD47)

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