Structure of PDB 7wao Chain A Binding Site BS02

Receptor Information
>7wao Chain A (length=502) Species: 36329 (Plasmodium falciparum 3D7) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
AMANAVIGNVVTRFPPEPSGYLHVGHAKAAFLNNYYAQMYEGKMLLRFDD
TNPVLEDIKYEKSIIEDLENLGLKYEKISYSSDHFDLLEKYCIDMIKMNK
AYADDTGVEDMRNQRGEGIESINRNNSIEKNLELFNEMRKGTEIGQKNCI
RAKINMQSKNKCMRDPVMYRCIVDVPHHKHQFKYKCYPTYDFACPIIDSI
EGVTHALRTNEYSDRIEQYNWFISTLNLRKVYIYEFSRLAFVKTVMSKRK
LKWFVENNVVDSWVDPRFPTIKGILRRGLTKEALFQFILEQGPSKAGNLM
QWDKLWSINKQIIDPIIPRYAAVDKNSSILLILTDLTDQVIQKERDLHMK
NKSLGTCNMYYNNKYLIELEDAQTLLENEEITLIKLGNIIIKNIEIKQIN
ALSNFHGDFKTTKKKIHWLPYLPQQLITCTLYEYDHLITVDKFDWTNFIN
FNSKHETLVYAEPSISSLKVSDKFQFERRGYFILDKIDPHHHLHLIKIPD
GK
Ligand information
Ligand IDMN
InChIInChI=1S/Mn/q+2
InChIKeyWAEMQWOKJMHJLA-UHFFFAOYSA-N
SMILES
SoftwareSMILES
ACDLabs 10.04
OpenEye OEToolkits 1.5.0		[Mn+2]
CACTVS 3.341[Mn++]
FormulaMn
NameMANGANESE (II) ION
ChEMBL
DrugBankDB06757
ZINC
PDB chain7wao Chain A Residue 1002 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
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PDB7wao Structural characterization of glutamyl-tRNA synthetase (GluRS) from Plasmodium falciparum.
Resolution2.582 Å
Binding residue
(original residue number in PDB)		D741 H767
Binding residue
(residue number reindexed from 1)		D435 H455
Annotation score1
Enzymatic activity
Enzyme Commision number 6.1.1.17: glutamate--tRNA ligase.
Gene Ontology
Molecular Function
GO:0000166 nucleotide binding
GO:0004812 aminoacyl-tRNA ligase activity
GO:0004818 glutamate-tRNA ligase activity
GO:0005524 ATP binding
Biological Process
GO:0006412 translation
GO:0006418 tRNA aminoacylation for protein translation
GO:0006424 glutamyl-tRNA aminoacylation
GO:0043039 tRNA aminoacylation
Cellular Component
GO:0005737 cytoplasm

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:7wao, PDBe:7wao, PDBj:7wao
PDBsum7wao
PubMed36370911
UniProtQ8IDK7

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