Structure of PDB 7w4a Chain A Binding Site BS02

Receptor Information
>7w4a Chain A (length=984) Species: 9823 (Sus scrofa) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
INDHQLSVAELEQKYQTSATKGLSASLAAELLLRDGPNALRPPRGTPEYV
KFARQLAGGLQCLMWVAAAICLIAFAIQASEGDLTTDDNLYLALALIAVV
VVTGCFGYYQEFKSTNIIASFKNLVPQQATVIRDGDKFQINADQLVVGDL
VEMKGGDRVPADIRILQAQGCKVDNSSLTGESEPQTRSPECTHESPLETR
NIAFFSTMCLEGTAQGLVVNTGDRTIIGRIASLASGVENEKTPIAIEIEH
FVDIIAGLAILFGATFFIVAMCIGYTFLRAMVFFMAIVVAYVPEGLLATV
TVCLSLTAKRLASKNCVVKNLEAVETLGSTSVICSDKTGTLTQNRMTVSH
LWFDNHIHSADTTEDQSGQTFDQSSETWRALCRVLTLCNRAAFKSGQDAV
PVPKRIVIGDASETALLKFSELTLGNAMGYRERFPKVCEIPFNSTNKFQL
SIHTLEDPRDPRHVLVMKGAPERVLERCSSILIKGQELPLDEQWREAFQT
AYLSLGGLGERVLGFCQLYLSEKDYPPGYAFDVEAMNFPTSGLCFAGLVS
MIDPPRATVPDAVLKCRTAGIRVIMVTGDHPITAKAIAASVGIISEGSET
VEDIAARLRVPVDQVNRKDARACVINGMQLKDMDPSELVEALRTHPEMVF
ARTSPQQKLVIVESCQRLGAIVAVTGDGVNDSPALKKADIGVAMGIAGSD
AAKNAADMILLDDNFASIVTGVEQGRLIFDNLKKSIAYTLTKNIPELTPY
LIYITVSVPLPLGCITILFIELCTDIFPSVSLAYEKAESDIMHLRPRNPK
RDRLVNEPLAAYSYFQIGAIQSFAGFTDYFTAMAQEGWFPLLCVGLRPQW
ENHHLQDLQDSYGQEWTFGQRLYQQYTCYTVFFISIEMCQIADVLIRKTR
RLSAFQQGFFRNRILVIAIVFQVCIGCFLCYCPGMPNIFNFMPIRFQWWL
VPMPFSLLIFVYDEIRKLGVRCCPGSWWDQELYY
Ligand information
Ligand IDMG
InChIInChI=1S/Mg/q+2
InChIKeyJLVVSXFLKOJNIY-UHFFFAOYSA-N
SMILES
SoftwareSMILES
ACDLabs 10.04
OpenEye OEToolkits 1.5.0		[Mg+2]
CACTVS 3.341[Mg++]
FormulaMg
NameMAGNESIUM ION
ChEMBL
DrugBankDB01378
ZINC
PDB chain7w4a Chain A Residue 1103 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
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PDB7w4a Structural Basis for Binding of Potassium-Competitive Acid Blockers to the Gastric Proton Pump.
Resolution2.76 Å
Binding residue
(original residue number in PDB)		X385 T387 D726
Binding residue
(residue number reindexed from 1)		X336 T338 D677
Annotation score1
Enzymatic activity
Enzyme Commision number 7.2.2.19: H(+)/K(+)-exchanging ATPase.
Gene Ontology
Molecular Function
GO:0000166 nucleotide binding
GO:0000287 magnesium ion binding
GO:0005215 transporter activity
GO:0005391 P-type sodium:potassium-exchanging transporter activity
GO:0005515 protein binding
GO:0005524 ATP binding
GO:0008556 P-type potassium transmembrane transporter activity
GO:0008900 P-type potassium:proton transporter activity
GO:0016887 ATP hydrolysis activity
GO:0030955 potassium ion binding
GO:0046872 metal ion binding
Biological Process
GO:0006813 potassium ion transport
GO:0006883 intracellular sodium ion homeostasis
GO:0010248 establishment or maintenance of transmembrane electrochemical gradient
GO:0030007 intracellular potassium ion homeostasis
GO:0036376 sodium ion export across plasma membrane
GO:0071805 potassium ion transmembrane transport
GO:1902600 proton transmembrane transport
GO:1990573 potassium ion import across plasma membrane
Cellular Component
GO:0005886 plasma membrane
GO:0005889 potassium:proton exchanging ATPase complex
GO:0016020 membrane
GO:0016324 apical plasma membrane

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:7w4a, PDBe:7w4a, PDBj:7w4a
PDBsum7w4a
PubMed35604136
UniProtP19156|ATP4A_PIG Potassium-transporting ATPase alpha chain 1 (Gene Name=ATP4A)

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