Structure of PDB 7vg2 Chain A Binding Site BS02

Receptor Information
>7vg2 Chain A (length=845) Species: 3702 (Arabidopsis thaliana) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
SAAGSKKRKELHGTTCANALSGTWGENIDGATFQAYKFDFCCNISGEVYS
SFSLLLESTLAEDVGKVEMDLYLVRKLVKASVSPCGQIRLSQEELVKAKY
FQQFFFNGMFGKLFVGEFLLQTDTSSLWHPAFMFLLLPVETATIDWSAIN
SCASIVEFLKKNNLIHFANASSDKNSLEELVVIAIHTGRIYSIVEAVSDS
SAMSPFGYATYAEYFNKKYGIVLAHPNQPLMKLKQSHHAHNLLVDFNEEV
RKRKPNIHAHLPPELLARIDVPRAVLKSIYLLPSVMHRLESLMLASQLRE
EIDCSIDNFSISSTSILEAVTTLTCPESFSMERLELLGDSVLKYVASCHL
FLKYPDKDEGQLSRQRQSIISNSNLHRLTTSRKLQGYIRNGAFEPRRWTA
PGQFSLFPVPCKCGIDTREVPLDPKFFTENMTIKIGKSCDMGHRWVVSKS
VSDCAEALIGAYYVSGGLSASLHMMKWLGIDVDFDPNLVVEAINRVSLRC
YIPKEDELIELERKIQHEFSAKFLLKEAITHSSLRESYSYERLEFLGDSV
LDFLITRHLFNTYEQTGPGEMTDLRSACVNNENFAQVAVKNNLHTHLQRC
ATVLETQINDYLMSFQKPDETGRSIPSIQGPKALGDVVESIAGALLIDTR
LDLDQVWRVFEPLLSPLVTPDKLQLPPYRELNELCDSLGYFFRVKCSNDG
VKAQATIQLQLDDVLLTGDGSEQTNKLALGKAASHLLTQLEKRNVIPFIG
PINMKKGGPRGTLHEFCKKHLWPMPTFDTSEEKSRTPFEKRTSFSSFTST
ITLRIPNREAVMYAGEARPDKKSSFDSAVVELLYELERRKIVIIQ
Ligand information
>7vg2 Chain D (length=36) [Search RNA sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
augcagacuuaggaugaaugacucauucgcuuguuc
....................................
Receptor-Ligand Complex Structure
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PDB7vg2 Mechanism of siRNA production by a plant Dicer-RNA complex in dicing-competent conformation.
Resolution3.1 Å
Binding residue
(original residue number in PDB)		F869 Y883 K887 Y888 F915 R931 K934 H940 P1006 L1016 D1019 Q1047 N1052 A1072 K1114 K1117 R1215 P1248 G1249 T1252 R1255 V1283 Q1287 R1359 D1366 Q1403 T1404 N1405 K1474 G1475 R1478 H1482 M1492 R1503 F1518 K1546
Binding residue
(residue number reindexed from 1)		F206 Y214 K218 Y219 F246 R251 K254 H260 P326 L336 D339 Q367 N372 A392 K434 K437 R535 P568 G569 T572 R575 V603 Q607 R679 D686 Q723 T724 N725 K756 G757 R760 H764 M774 R785 F794 K822
Enzymatic activity
Enzyme Commision number 3.1.26.-
Gene Ontology
Molecular Function
GO:0003676 nucleic acid binding
GO:0003723 RNA binding
GO:0003725 double-stranded RNA binding
GO:0004386 helicase activity
GO:0004519 endonuclease activity
GO:0004525 ribonuclease III activity
GO:0005515 protein binding
GO:0005524 ATP binding
GO:0046872 metal ion binding
Biological Process
GO:0006396 RNA processing
GO:0006952 defense response
GO:0010267 ta-siRNA processing
GO:0030422 siRNA processing
GO:0031047 regulatory ncRNA-mediated gene silencing
GO:0051214 RNAi-mediated antiviral immunity against RNA virus
GO:0051607 defense response to virus
Cellular Component
GO:0005634 nucleus
GO:0005730 nucleolus

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:7vg2, PDBe:7vg2, PDBj:7vg2
PDBsum7vg2
PubMed34648373
UniProtQ9LXW7|DCL3_ARATH Endoribonuclease Dicer homolog 3 (Gene Name=DCL3)

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