Structure of PDB 7vdv Chain A Binding Site BS02

Receptor Information
>7vdv Chain A (length=809) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
RGPTPFNQNQLHQLRAQIMAYKMLARGQPLPDHLQMAVDPVEILQEREYR
LQARIAHRIQELENLPGSLAGDLRTKATIELKALRLLNFQRQLRQEVVVC
MRRDTALETALNAKAYKRSKRQSLREARITEKLEKQQKIEQERKRRQKHQ
EYLNSILQHAKDFKEYHRSVTGKIQKLTKAVATYHANTEREQKKKLIDQK
KDKRLAYLLQQTYYAVAHAVTERVDKQSALMVNGVLKQYQIKGLEWLVSL
YNNNLNGILADEMGLGKTIQTIALITYLMEHKRINGPFLIIVPLSTLSNW
AYEFDKWAPSVVKVSYKGSPAARRAFVPQLRSGKFNVLLTTYEYIIKDKH
ILAKIRWKYMIVDEGHRMKNHHCKLTQVLNTHYVAPRRLLLTGTPLQNKL
PELWALLNFLLPTIFKSCSTFEQWFNAPFAMTGEKVDLNEEETILIIRRL
HKVLRPFLLRRLKKEVEAQLPEKVEYVIKCDMSALQRVLYRHMQAKGVLL
TDGSGTKTLMNTIMQLRKICNHPYMFQHIEESFSEHLGFTGGIVQGLDLY
RASGKFELLDRILPKLRATNHKVLLFCQMTSLMTIMEDYFAYRGFKYLRL
DGTTKAEDRGMLLKTFNEPGSEYFIFLLSTRAGGLGLNLQSADTVIIFDS
DWNPHQDLQAQDRAHRIGQQNEVRVLRLCTVNSVEEKILAAAKYKLNVDQ
KVIQAGMFDQKSSSHERRAFLQAILEHEEQDEEEDEVPDDETVNQMIARH
EEEFDLFMRMDLDRRREEARNPKRKPRLMEEDELPSWIIKEKMFGRGSRH
RKEVDYSDS
Ligand information
>7vdv Chain J (length=137) [Search DNA sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
tcaggatgtatatatctgacacgtgcctggagactagggagtaatcccct
tggcggttaaaacgcgggggacagcgcgtacgtgcgtttaagcggtgcta
gagctgtctacgaccaattgagcggcctcggcaccgg
Receptor-Ligand Complex Structure
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PDB7vdv Structure of human chromatin-remodelling PBAF complex bound to a nucleosome.
Resolution3.4 Å
Binding residue
(original residue number in PDB)		L812 P838 R841 E861 Y862 K865 M1036 N1037 M1040 M1105 T1106 R1135 S1155
Binding residue
(residue number reindexed from 1)		L294 P320 R323 E343 Y344 K347 M510 N511 M514 M579 T580 R609 S629
Enzymatic activity
Enzyme Commision number 3.6.4.-
Gene Ontology
Molecular Function
GO:0005524 ATP binding
GO:0042393 histone binding
GO:0140658 ATP-dependent chromatin remodeler activity
Biological Process
GO:0006355 regulation of DNA-templated transcription
Cellular Component
GO:0005634 nucleus

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:7vdv, PDBe:7vdv, PDBj:7vdv
PDBsum7vdv
PubMed35477757
UniProtP51532|SMCA4_HUMAN Transcription activator BRG1 (Gene Name=SMARCA4)

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