Structure of PDB 7vdt Chain A Binding Site BS02

Receptor Information
>7vdt Chain A (length=617) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
KLIDQKKDKRLAYLLQQTDEYYAVAHAVTERVDKQSALMVNGVLKQYQIK
GLEWLVSLYNNNLNGILADEMGLGKTIQTIALITYLMEHKRINGPFLIIV
PLSTLSNWAYEFDKWAPSVVKVSYKGSPAARRAFVPQLRSGKFNVLLTTY
EYIIKDKHILAKIRWKYMIVDEGHRMKNHHCKLTQVLNTHYVAPRRLLLT
GTPLQNKLPELWALLNFLLPTIFKSCSTFEQWFNAPFAMTGEKVDLNEEE
TILIIRRLHKVLRPFLLRRLKKEVEAQLPEKVEYVIKCDMSALQRVLYRH
MQAKGVLLTDGSGTKTLMNTIMQLRKICNHPYMFQHIEESFSEHLGFTGG
IVQGLDLYRASGKFELLDRILPKLRATNHKVLLFCQMTSLMTIMEDYFAY
RGFKYLRLDGTTKAEDRGMLLKTFNEPGSEYFIFLLSTRAGGLGLNLQSA
DTVIIFDSDWNPHQDLQAQDRAHRIGQQNEVRVLRLCTVNSVEEKILAAA
KYKLNVDQKVIQAGMFDQKSSSHERRAFLQAILEHEEQDEEEDEVPDDET
VNQMIARHEEEFDLFMRMDLDRRREEARNPKRKPRLMEEDELPSWIIKEK
MFGRGSRHRKEVDYSDS
Ligand information
>7vdt Chain J (length=137) [Search DNA sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
tcaggatgtatatatctgacacgtgcctggagactagggagtaatcccct
tggcggttaaaacgcgggggacagcgcgtacgtgcgtttaagcggtgcta
gagctgtctacgaccaattgagcggcctcggcaccgg
Receptor-Ligand Complex Structure
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PDB7vdt Structure of human chromatin-remodelling PBAF complex bound to a nucleosome.
Resolution2.8 Å
Binding residue
(original residue number in PDB)		L812 R841 E861 Y862 K865 M1036 N1037 M1105 T1106 G1128 R1135 S1155 R1157 A1158
Binding residue
(residue number reindexed from 1)		L102 R131 E151 Y152 K155 M318 N319 M387 T388 G410 R417 S437 R439 A440
Enzymatic activity
Enzyme Commision number 3.6.4.-
Gene Ontology
Molecular Function
GO:0005524 ATP binding
GO:0042393 histone binding
GO:0140658 ATP-dependent chromatin remodeler activity
Biological Process
GO:0006355 regulation of DNA-templated transcription
Cellular Component
GO:0005634 nucleus

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:7vdt, PDBe:7vdt, PDBj:7vdt
PDBsum7vdt
PubMed35477757
UniProtP51532|SMCA4_HUMAN Transcription activator BRG1 (Gene Name=SMARCA4)

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