Structure of PDB 7vbc Chain A Binding Site BS02

Receptor Information
>7vbc Chain A (length=1477) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
NMPWRRLQGISFGMYSAEELKKLSVKSITNPRYLDSLGNPSANGLYDLAL
GPADSKEVCSTCVQDFSNCSGHLGHIELPLTVYNPLLFDKLYLLLRGSCL
NCHMLTCPRAVIHLLLCQLRVLEVGALQAVYELERILNRFSASEIREELE
QYTTEIVQNNLLGSQGAHVKNVCESKSKLIALFWKAHMNAKRCPHCKTGR
SVVRKEHNSKLTITFRGYLTPTSAREHLSALWKNEGFFLNYLFSRFNPSV
FFLDFLVVPPSRYRPVSRLGDQMFTNGQTVNLQAVMKDVVLIRKLLALMA
QEQSLIDKLYNIWIRLQSHVNIVFDSEMDKLMMDKYPGIRQILEKKEGLF
RKHMMGKRVDYAARSVICPDMYINTNEIGIPMVFATKLTYPQPVTPWNVQ
ELRQAVINGPNVHPGASMVINEDGSRTALSAVDMTQREAVAKQLLTQGTK
IVCRHVKNGDILLLNRQPTLHRPSIQAHRARILPEEKVLRLHYANCKAYN
ADFDGDEMNAHFPQSELGRAEAYVLACTDQQYLVPKDGQPLAGLIQDHMV
SGASMTTRGCFFTREHYMELVYRGLTDKVGRVKLLSPSILKPFPLWTGKQ
VVSTLLINIIPEDHIPLNLSGKAKITGKAWVKETPRSVPGFNPDSMCESQ
VIIREGELLCGVLDKAHYGSSAYGLVHCCYEIYGGETSGKVLTCLARLFT
AYLQLYRGFTLGVEDILVKPKADVKRQRIIEESTHCGPQAVRAALNLPEA
ASYDEVRGKWQDAHLGKDQRDFNMIDLKFKEEVNHYSNEINKACMPFGLH
RQFPENSLQMMVQSGAKGSTVNTMQISCLLGQIELEGRRPPLMASGKSLP
CFEPYEFTPRAGGFVTGRFLTGIKPPEFFFHCMAGREGLVDTAVKTSRSG
YLQRCIIKHLEGLVVQYDLTVRDSDGSVVQFLYGEDGLDIPKTQFLQPKQ
FPFLASNYEVIMKSQHLHEVLSRADPKKALHHFRAIKKWQSKHPNTLLRR
GAFLSYSQKIQEAVKALKLESENRNGRSPGTQEMLRMWYELDEESRRKYQ
KKAAACPDPSLSVWRPDIYFASVSETFETKVDDYSQEWAAQTEKSYEKSE
LSLDRLRTLLQLKWQRSLCEPGEAVGLLAAQSIGEPSTQMMNVTLGIPRL
REILMVASANIKTPMMSVPVLNTKKALKRVKSLKKQLTRVCLGEVLQKID
VQEQVYQLRFQFLPHAYYQQEKCLRPEDILRFMETRFFKLLMESIKKKNN
KASEAMERRVQAVREIHPFIDDYQYDTEESLWCQVTVKLPLMKINFDMSS
LVVSLAHGAVIYATKGITRCLLNETTNNKNEKELVLNTEGINLPELFKYA
EVLDLRRLYSNDIHAIANTYGIEAALRVIEKEIKDVFAVYGIAVDPRHLS
LVADYMCFEGVYKPLNRFGIRSNSSPLQQMTFETSFQFLKQATMLGSHDE
LRSPSACLVVGKVVRGGTGLFELKQPL
Ligand information
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB7vbc Structure of the human RNA polymerase I elongation complex.
Resolution3.01 Å
Binding residue
(original residue number in PDB)		L315 G316 R418 K423 K424 R429 Q553 R1659 T1676
Binding residue
(residue number reindexed from 1)		L269 G270 R340 K345 K346 R351 Q467 R1417 T1434
Enzymatic activity
Enzyme Commision number 2.7.7.6: DNA-directed RNA polymerase.
Gene Ontology
Molecular Function
GO:0000287 magnesium ion binding
GO:0001054 RNA polymerase I activity
GO:0003677 DNA binding
GO:0003682 chromatin binding
GO:0003899 DNA-directed 5'-3' RNA polymerase activity
GO:0005515 protein binding
GO:0008270 zinc ion binding
GO:0016779 nucleotidyltransferase activity
GO:0034062 5'-3' RNA polymerase activity
GO:0046872 metal ion binding
GO:0071667 DNA/RNA hybrid binding
Biological Process
GO:0006351 DNA-templated transcription
GO:0006360 transcription by RNA polymerase I
GO:1904750 negative regulation of protein localization to nucleolus
Cellular Component
GO:0000428 DNA-directed RNA polymerase complex
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005694 chromosome
GO:0005730 nucleolus
GO:0005736 RNA polymerase I complex

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:7vbc, PDBe:7vbc, PDBj:7vbc
PDBsum7vbc
PubMed34671025
UniProtO95602|RPA1_HUMAN DNA-directed RNA polymerase I subunit RPA1 (Gene Name=POLR1A)

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