Structure of PDB 7v74 Chain A Binding Site BS02

Receptor Information

>7v74 Chain A (length=597) Species: 9606 (Homo sapiens)

KNLLLSFFPILEWLPKYNLKEWLLGDLIAGLTVGSLQIPQGIAFALLAGL
PPIYGLYSSFFPPLIYAFFGTSRHISVGPFAVVSLLVGSVVERLVPDDNG
TEARDALRVQVAFTLTFLAGIIQLALGLLRLGFLVDFLSEPLISGFTTGA
AIHILLSQLKYLLGLKIPRHSGPFSVIYSVISVFHNIPNTNIATLGVSLL
SFVLLLVVKELNKRFKKKLPVPIPAELIVVILATLISYYFNLAEKYGVSI
VGHIPKGLPPPSVPDLSLFPLVIGDAIAIAIVGLAVSISVGKTFAKKHGY
QIDGNQELIALGLMNIVGSFFSCYPATGSFSRSAVNESAGGKTQVAGIVA
ALVVLLVLLFLGPLFYYLPKAVLAAIIIVNLKGLLMQFKDAPKLWKVDKL
DFLIWLVTFLGVVFLSVEIGLLVGVGFSLLTVLLRTQRPRTSVLGRIPGT
DIYRDVKQYPEAEEVPGVKIFRIDSPIYFANSEYFKERLKRKTGVDPVKV
LAARKKALKKIVDFHTLILDFSAVSFVDTVGVKTLKEIVKEYREIGVQVY
LAGCNASVVEKLERGGFFDDGITKEHLFLSVHDAVLFAQARKALAEQ

Ligand information

• Ligand ID: CLR
• InChI: InChI=1S/C27H46O/c1-18(2)7-6-8-19(3)23-11-12-24-22-10-9-20-17-21(28)13-15-26(20,4)25(22)14-16-27(23,24)5/h9,18-19,21-25,28H,6-8,10-17H2,1-5H3/t19-,21+,22+,23-,24+,25+,26+,27-/m1/s1
• InChIKey: HVYWMOMLDIMFJA-DPAQBDIFSA-N
• SMILES:
  OpenEye OEToolkits 1.5.0: CC(C)CCCC(C)C1CCC2C1(CCC3C2CC=C4C3(CCC(C4)O)C)C
  CACTVS 3.341: CC(C)CCC[C@@H](C)[C@H]1CC[C@H]2[C@@H]3CC=C4C[C@@H](O)CC[C@]4(C)[C@H]3CC[C@]12C
  ACDLabs 10.04: OC4CCC3(C(=CCC2C1C(C(C(C)CCCC(C)C)CC1)(C)CCC23)C4)C
  OpenEye OEToolkits 1.5.0: CC(C)CCC[C@@H](C)[C@H]1CC[C@@H]2[C@@]1(CC[C@H]3[C@H]2CC=C4[C@@]3(CC[C@@H](C4)O)C)C
  CACTVS 3.341: CC(C)CCC[CH](C)[CH]1CC[CH]2[CH]3CC=C4C[CH](O)CC[C]4(C)[CH]3CC[C]12C
• Formula: C27 H46 O
• Name: CHOLESTEROL
• ChEMBL: CHEMBL112570
• DrugBank: DB04540
• ZINC: ZINC000003875383
• PDB chain: 7v74 Chain A Residue 803

Receptor-Ligand Complex Structure

Structure summary

• PDB: 7v74 Cryo-EM structures of thermostabilized prestin provide mechanistic insights underlying outer hair cell electromotility.
• Resolution: 3.63 Å
• Binding residue (original residue number in PDB): L273 K276 V446
• Binding residue (residue number reindexed from 1): L206 K209 V379
• Annotation score: 1

Gene Ontology

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UnboundLocalError

Python 3.6.8: /usr/bin/python3 Sun Dec 1 13:38:46 2024

A problem occurred in a Python script. Here is the sequence of function calls leading up to the error, in the order they occurred.

 /var/www/html/BioLiP/pdb.cgi in <module>()

   1435     title=pdb2title(pdbid)

   1436     if bs.startswith("BS"):

=> 1437         pubmed,uniprot=display_interaction(pdbid,asym_id,bs,title)

   1438     else:

   1439         if lig3:

pubmed = '', uniprot = '', display_interaction = <function display_interaction>, pdbid = '7v74', asym_id = 'A', bs = 'BS02', title = 'Cryo-EM structures of thermostabilized prestin p...ights underlying outer hair cell electromotility.'

 /var/www/html/BioLiP/pdb.cgi in display_interaction(pdbid='7v74', asym_id='A', bs='BS02', title='Cryo-EM structures of thermostabilized prestin p...ights underlying outer hair cell electromotility.')

   1295         display_ec(ec,csaOrig,csaRenu)

   1296     if go:

=> 1297         display_go(go,uniprot,pdbid,asym_id)

   1298     return pubmed,uniprot

   1299 

global display_go = <function display_go>, go = '0008271,0008272,0016020,0055085', uniprot = '', pdbid = '7v74', asym_id = 'A'

 /var/www/html/BioLiP/pdb.cgi in display_go(go='0008271,0008272,0016020,0055085', uniprot='', pdbid='7v74', asym_id='A')

    480         '''.replace("$namespace_link",namespace_link

    481           ).replace("$namespace",namespace

=>  482           ).replace("$uniprot",u

    483         ))

    484         for l,(term,name) in enumerate(go2aspect[Aspect]):

u undefined

UnboundLocalError: local variable 'u' referenced before assignment
      args = ("local variable 'u' referenced before assignment",)
      with_traceback = <built-in method with_traceback of UnboundLocalError object>