Structure of PDB 7uyz Chain A Binding Site BS02
Receptor Information
>7uyz Chain A (length=353) Species:
10090
(Mus musculus) [
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KLKKVLDKLRLKRKDISEAAETVNKVVERLLRRMQKRESEFKGVEQLNTG
SYYEHVKISAPNEFDVMFKLEVPRIELQEYYETGAFYLVKFGNPLSHFLE
GEVLSATKMLSKFRKIIKEEVKEIKDIDVSVEKEKPGSPAVTLLIRNPEE
ISVDIILALESKGSWPISTKEGLPIQGWLGTKVRTNLRREPFYLVPKNAK
DGNSFQGETWRLSFSHTEKYILNNHGIEKTCCESSGAKCCRKECLKLMKY
LLEQLKKEFQELDAFCSYHVKTAIFHMWTQDPQDSQWDPRNLSSCFDKLL
AFFLECLRTEKLDHYFIPKFNLFSQELIDRKSKEFLSKKIEYERNNGFPI
FDK
Ligand information
>7uyz Chain F (length=18) [
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atctgtacatgtacagat
Receptor-Ligand Complex Structure
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PDB
7uyz
Structure of Ternary Complex of cGAS with dsDNA and Bound 5 -pppG(2 ,5 )pG
Resolution
2.49 Å
Binding residue
(original residue number in PDB)
R161 S165 A168 Y200 Y201 K372
Binding residue
(residue number reindexed from 1)
R13 S17 A20 Y52 Y53 K219
Enzymatic activity
Enzyme Commision number
2.7.7.86
: cyclic GMP-AMP synthase.
External links
PDB
RCSB:7uyz
,
PDBe:7uyz
,
PDBj:7uyz
PDBsum
7uyz
PubMed
UniProt
Q8C6L5
|CGAS_MOUSE Cyclic GMP-AMP synthase (Gene Name=Cgas)
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