Structure of PDB 7uxw Chain A Binding Site BS02
Receptor Information
>7uxw Chain A (length=346) Species:
10090
(Mus musculus) [
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DKLKKVLDKLRLKRKDISEAAETVNKVVERLLRRMQKESEFKGVEQLNTG
SYYEHVKISAPNQFNVMFKLEVPRIELQEYYETGAFYLVKFGPLSHFLEG
VLSATKMLSKFRKIIKEEVKEIKDIDVSVEKEKPGSPAVTLLIRNPEEIS
VDIILALESKGSWPISTKEGLPIQGWLGTKVRTNLRREPFYLVPKNAQGE
TWRLSFSHTEKYILNNHGIEKTCCESSGAKCCRKECLKLMKYLLEQLKKE
FQELDAFCSYHVKTAIFHMWTQDPQDSQWDPRNLSSCFDKLLAFFLECLR
TEKLDHYFIPKFNLFSQELIDRKSKEFLSKKIEYERNNGFPIFDKL
Ligand information
>7uxw Chain F (length=18) [
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atctgtacatgtacagat
Receptor-Ligand Complex Structure
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PDB
7uxw
ATP and GTP bind to Cyclic GMP AMP synthase (cGAS) through Mg coordination
Resolution
2.57 Å
Binding residue
(original residue number in PDB)
R161 S165 A168 N196 Y200 Y201 K372
Binding residue
(residue number reindexed from 1)
R14 S18 A21 N48 Y52 Y53 K211
Enzymatic activity
Enzyme Commision number
2.7.7.86
: cyclic GMP-AMP synthase.
External links
PDB
RCSB:7uxw
,
PDBe:7uxw
,
PDBj:7uxw
PDBsum
7uxw
PubMed
UniProt
Q8C6L5
|CGAS_MOUSE Cyclic GMP-AMP synthase (Gene Name=Cgas)
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