Structure of PDB 7uva Chain A Binding Site BS02

Receptor Information
>7uva Chain A (length=329) Species: 10090 (Mus musculus) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
RTFDLEEKLQTNKYNANFVTFMEGKDFNVEYIQRGGLRDPLIFKNSDGLG
IKMPDPDFTVNDVKMCVGSRRMVDVMDVNTQKGIEMTMAQWTRYYETPEE
EREKLYNVISLEFSHTRLENMVQRPSTVDFIDWVDNMWPRHLKESQTEST
NAILEMQYPKVQKYCLMSVRGCYTDFHVDFGGTSVWYHIHQGGKVFWLIP
PTAHNLELYENWLLSGKQGDIFLGDRVSDCQRIELKQGYTFVIPSGWIHA
VYTPTDTLVFGGNFLHSFNIPMQLKIYSIEDRTRVPNKFRYPFYYEMCWY
VLERYVYCITNRSHLTKDFQKESLSMDME
Ligand information
Ligand IDFE
InChIInChI=1S/Fe/q+3
InChIKeyVTLYFUHAOXGGBS-UHFFFAOYSA-N
SMILES
SoftwareSMILES
ACDLabs 10.04
CACTVS 3.341
OpenEye OEToolkits 1.5.0		[Fe+3]
FormulaFe
NameFE (III) ION
ChEMBL
DrugBankDB13949
ZINC
PDB chain7uva Chain A Residue 401 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

[Spin on] [Spin off] [Reset]
[High quality] [Low quality]
[White background] [Black background]
[Spin on] [Spin off] [Reset]
[High quality] [Low quality]
[White background] [Black background]
PDB7uva Structural basis of paralog-specific KDM2A/B nucleosome recognition.
Resolution1.98 Å
Binding residue
(original residue number in PDB)		H212 D214 H284
Binding residue
(residue number reindexed from 1)		H177 D179 H249
Annotation score1
Enzymatic activity
Enzyme Commision number 1.14.11.27: [histone H3]-dimethyl-L-lysine(36) demethylase.
External links
PDB RCSB:7uva, PDBe:7uva, PDBj:7uva
PDBsum7uva
PubMed36797403
UniProtP59997|KDM2A_MOUSE Lysine-specific demethylase 2A (Gene Name=Kdm2a)

[Back to BioLiP]