Structure of PDB 7uv0 Chain A Binding Site BS02

Receptor Information
>7uv0 Chain A (length=501) Species: 10116 (Rattus norvegicus) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
ATFGAWDYGVFATMLLVSTGIGLWVGLAVPVGLSLAASFMSAVQVLGVPA
EAARYGLKFLWMCAGQLLNSLLTAFLFLPIFYRLGLTSTYQYLELRFSRA
VRLCGTLQYLVATMLYTGIVIYAPALILNQVTGLDIWASLLSTGIICTLY
TTVGGTDVFQVVVMLVGFWVILARGVILLGGPRNVLSLAQQHSRINLMDF
DPDPRSRYTFWTFIVGGTLVWLSMYGVNQAQVQRYVACHTEGKAKLALLV
NQLGLFLIVASAACCGIVMFVYYKDCDPLLTGRISAPDQYMPLLVLDIFE
DLPGVPGLFLACAYSGTLSTASTSINAMAAVTVEDLIKPRMPGLAPRKLV
FISKGLSFIYGSACLTVAALSSLLGGGVLQGSFTVMGVISGPLLGAFTLG
MLLPACNTPGVLSGLAAGLAVSLWVAVGATLYPPGEQTMGVLPTSAAGCG
RPALADTFYAISYLYYGALGTLTTMLCGALISYLTGPTKRSSLGPGLLWW
D
Ligand information
Ligand IDNA
InChIInChI=1S/Na/q+1
InChIKeyFKNQFGJONOIPTF-UHFFFAOYSA-N
SMILES
SoftwareSMILES
ACDLabs 10.04
CACTVS 3.341
OpenEye OEToolkits 1.5.0		[Na+]
FormulaNa
NameSODIUM ION
ChEMBL
DrugBankDB14516
ZINC
PDB chain7uv0 Chain A Residue 702 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
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PDB7uv0 Structural insights into the mechanism of the sodium/iodide symporter.
Resolution3.1 Å
Binding residue
(original residue number in PDB)		F67 S69 V71 Q72 Y144
Binding residue
(residue number reindexed from 1)		F39 S41 V43 Q44 Y116
Annotation score5
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0008507 sodium:iodide symporter activity
GO:0015111 iodide transmembrane transporter activity
GO:0015293 symporter activity
GO:0015373 monoatomic anion:sodium symporter activity
GO:0022857 transmembrane transporter activity
GO:0042803 protein homodimerization activity
Biological Process
GO:0006590 thyroid hormone generation
GO:0006814 sodium ion transport
GO:0015705 iodide transport
GO:0035725 sodium ion transmembrane transport
GO:0055085 transmembrane transport
GO:0071320 cellular response to cAMP
GO:0071371 cellular response to gonadotropin stimulus
GO:0098656 monoatomic anion transmembrane transport
GO:1904200 iodide transmembrane transport
GO:1904322 cellular response to forskolin
GO:1904401 cellular response to Thyroid stimulating hormone
Cellular Component
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0005886 plasma membrane
GO:0016020 membrane

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:7uv0, PDBe:7uv0, PDBj:7uv0
PDBsum7uv0
PubMed36517601
UniProtQ63008|SC5A5_RAT Sodium/iodide cotransporter (Gene Name=Slc5a5)

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