Structure of PDB 7uu3 Chain A Binding Site BS02

Receptor Information

>7uu3 Chain A (length=369) Species: 9544 (Macaca mulatta)

MVEPMDPRTFVSNFNNRPILSGLDTVWLCCEVKTKDPSGPPLDAKIFQGK
VYPKAKYHPEMRFLRWFHKWRQLHHDQEYKVTWYVSWSPCTRCANSVATF
LAKDPKVTLTIFVARLYYFWKPDYQQALRILAEAGATMKIMNYNEFQDCW
NKFVDGRGKPFKPWNNLPKHYTLLQATLGELLRHLMDPGTFTSNFNNKPW
VSGQHETYLCYKVERLHNDTWVPLNQHRGFLRNQAPNIHGFPKGRHAALC
FLDLIPFWKLDGQQYRVTCFTSWSPCFSCAQEMAKFISNNEHVSLCIFAA
RIYDDQGRYQEGLRTLHRDGAKIAMMNYSEFEYCWDTFVDRQGRPFQPWD
GLDEHSQALSGRLRAILQN

Ligand information

• Ligand ID: ZN
• InChI: InChI=1S/Zn/q+2
• InChIKey: PTFCDOFLOPIGGS-UHFFFAOYSA-N
• SMILES:
  CACTVS 3.341: [Zn++]
  ACDLabs 10.04
  OpenEye OEToolkits 1.5.0: [Zn+2]
• Formula: Zn
• Name: ZINC ION
• ChEMBL: CHEMBL1236970
• DrugBank: DB14532
• PDB chain: 7uu3 Chain A Residue 401

Receptor-Ligand Complex Structure

Structure summary

• PDB: 7uu3 Structural basis of sequence-specific RNA recognition by the antiviral factor APOBEC3G.
• Resolution: 3.099 Å
• Binding residue (original residue number in PDB): H65 C97 C100
• Binding residue (residue number reindexed from 1): H58 C90 C93
• Annotation score: 1

Enzymatic activity

• Enzyme Commision number: 3.5.4.-
  3.5.4.38: single-stranded DNA cytosine deaminase.

Gene Ontology

Molecular Function

• GO:0003824 catalytic activity
• GO:0004126 cytidine deaminase activity
• GO:0008270 zinc ion binding
• GO:0016787 hydrolase activity
• GO:0046872 metal ion binding

Biological Process

• GO:0009972 cytidine deamination
• GO:0010526 retrotransposon silencing
• GO:0045087 innate immune response
• GO:0051607 defense response to virus
• GO:0070383 DNA cytosine deamination

Cellular Component

• GO:0000932 P-body
• GO:0005634 nucleus
• GO:0005737 cytoplasm
• GO:1990904 ribonucleoprotein complex

External links

• PDB: RCSB:7uu3, PDBe:7uu3, PDBj:7uu3
• PDBsum: 7uu3
• PubMed: 36470880
• UniProt: M1GSK9