Structure of PDB 7usm Chain A Binding Site BS02

Receptor Information
>7usm Chain A (length=848) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
FNLDTENAMTFQENARGFGQSVVQLQGSRVVVGAPQEIVAANQRGSLYQC
DYSTGSCEPIRLQVPVEAVNMSLGLSLAATTSPPQLLACGPTVHQTCSEN
TYVKGLCFLFGSNLRQQPQKHEMSQEGFSAAITSNGPLLSTVGSYDWAGG
VFLYTSKEKSTFINMTRVDSDMNDAYLGYAAAIILRNRVQSLVLGAPRYQ
HIGLVAMFRQNTGMWESNANVKGTQIGAYFGASLCSVDVDSNGSTDLVLI
GAPHYYEQTRGGQVSVCPLPRGRARWQCDAVLYGEQGQPWGRFGAALTVL
GDVNGDKLTDVAIGAPGEEDNRGAVYLFHGTSGSGISPSHSQRIAGSKLS
PRLQYFGQSLSGGQDLTMDGLVDLTVGAQGHVLLLRSQPVLRVKAIMEFN
PREVARNVFECGKEAGEVRVCLHVQKSTRDRLREGQIQSVVTYDLALDSG
RPHSRAVFNETKNSTRRQTQVLGLTQTCETLKLQLPNCIEDPVSPIVLRL
NFSLVGTPLSAFGNLRPVLAEDAQRLFTALFPFEKNCGNDNICQDDLSIT
FSFMSLDCLVVGGPREFNVTVTVRNDGEDSYRTQVTFFFPLDLSYRKVST
WRLACESLKSTSCSINHPIFPENSEVTFNITFDVDSKASLGNKLLLKANV
TSENNMPRTNKTEFQLELPVKYAVYMVVTSHGVSTKYLNFTASENTSRVM
QHQYQVSNLGQRSLPISLVFLVPVRLNQTVIWDRPQVTFSENLSSTCHTK
ERLPSHSDFLAELRKAPVVNCSIAVCQRIQCDIPFFGIQEEFNATLKGNL
SFDWYIKTSHNHLLIVSTAEILFNDSVFTLLPGQGAFVRSQTETKVEP
Ligand information
Ligand IDCA
InChIInChI=1S/Ca/q+2
InChIKeyBHPQYMZQTOCNFJ-UHFFFAOYSA-N
SMILES
SoftwareSMILES
CACTVS 3.341[Ca++]
ACDLabs 10.04
OpenEye OEToolkits 1.5.0		[Ca+2]
FormulaCa
NameCALCIUM ION
ChEMBL
DrugBankDB14577
ZINC
PDB chain7usm Chain A Residue 1202 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB7usm Structural basis for non-canonical integrin engagement by Bordetella adenylate cyclase toxin.
Resolution2.7 Å
Binding residue
(original residue number in PDB)		D513 N515 D517 L519 D521
Binding residue
(residue number reindexed from 1)		D302 N304 D306 L308 D310
Annotation score4
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0001540 amyloid-beta binding
GO:0001851 complement component C3b binding
GO:0005178 integrin binding
GO:0005515 protein binding
GO:0031072 heat shock protein binding
GO:0038024 cargo receptor activity
GO:0044877 protein-containing complex binding
GO:0046872 metal ion binding
Biological Process
GO:0001774 microglial cell activation
GO:0002430 complement receptor mediated signaling pathway
GO:0002931 response to ischemia
GO:0006898 receptor-mediated endocytosis
GO:0006911 phagocytosis, engulfment
GO:0007155 cell adhesion
GO:0007160 cell-matrix adhesion
GO:0007229 integrin-mediated signaling pathway
GO:0009612 response to mechanical stimulus
GO:0010668 ectodermal cell differentiation
GO:0030900 forebrain development
GO:0032355 response to estradiol
GO:0032930 positive regulation of superoxide anion generation
GO:0033627 cell adhesion mediated by integrin
GO:0034113 heterotypic cell-cell adhesion
GO:0043315 positive regulation of neutrophil degranulation
GO:0045087 innate immune response
GO:0045963 negative regulation of dopamine metabolic process
GO:0090314 positive regulation of protein targeting to membrane
GO:0097242 amyloid-beta clearance
GO:0098609 cell-cell adhesion
GO:0098742 cell-cell adhesion via plasma-membrane adhesion molecules
GO:0140459 response to Gram-positive bacterium
GO:0150062 complement-mediated synapse pruning
GO:0150064 vertebrate eye-specific patterning
GO:1904151 positive regulation of microglial cell mediated cytotoxicity
GO:1904643 response to curcumin
GO:2000363 positive regulation of prostaglandin-E synthase activity
Cellular Component
GO:0005615 extracellular space
GO:0005886 plasma membrane
GO:0008305 integrin complex
GO:0009897 external side of plasma membrane
GO:0009986 cell surface
GO:0034688 integrin alphaM-beta2 complex
GO:0035579 specific granule membrane
GO:0044853 plasma membrane raft
GO:0045121 membrane raft
GO:0070062 extracellular exosome
GO:0070821 tertiary granule membrane

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Molecular Function
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Biological Process
View graph for
Cellular Component
External links
PDB RCSB:7usm, PDBe:7usm, PDBj:7usm
PDBsum7usm
PubMed35977491
UniProtP11215|ITAM_HUMAN Integrin alpha-M (Gene Name=ITGAM)

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