Structure of PDB 7ura Chain A Binding Site BS02

Receptor Information
>7ura Chain A (length=432) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
FSRQEFFQQLLQGCLLPTAQQGLDQIWLLLAICLACRLLWRLGLPSYLKH
ASTVAGGFFSLYHFFQLHMVWVVLLSLLCYLVLFLCRHSSHRGVFLSVTI
LIYLLMGEMHMVDTVTWHKMRGAQMIVAMKAVSLGFDLDRGEVGTVPSPV
EFMGYLYFVGTIVFGPWISFHSYLQAVQGRPLSCRWLQKVARSLALALLC
LVLSTCVGPYLFPYFIPLNARWLRAYESAVSFHFSNYFVGFLSEATATLA
GAGFTEEKDHLEWDLTVSKPLNVELPRSMVEVVTSWNLPMSYWLNNYVFK
NALRLGTFSAVLVTYAASALLHGFSFHLAAVLLSLAFITYVEHVLRKRLA
RILSACVLSKRCPPDCSHQHRLGLGVRALNLLFGALAIFHLAYLGSLFDV
YGMAYTVHKWSELSWASHWVTFGCWIFYRLIG
Ligand information
Ligand IDZN
InChIInChI=1S/Zn/q+2
InChIKeyPTFCDOFLOPIGGS-UHFFFAOYSA-N
SMILES
SoftwareSMILES
CACTVS 3.341[Zn++]
ACDLabs 10.04
OpenEye OEToolkits 1.5.0		[Zn+2]
FormulaZn
NameZINC ION
ChEMBLCHEMBL1236970
DrugBankDB14532
ZINC
PDB chain7ura Chain A Residue 502 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
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PDB7ura Mechanisms and inhibition of Porcupine-mediated Wnt acylation.
Resolution3.11 Å
Binding residue
(original residue number in PDB)		C370 C376 C380 H382
Binding residue
(residue number reindexed from 1)		C356 C362 C366 H368
Annotation score1
Enzymatic activity
Enzyme Commision number 2.3.1.250: [Wnt protein] O-palmitoleoyl transferase.
Gene Ontology
Molecular Function
GO:0016746 acyltransferase activity
GO:0017147 Wnt-protein binding
GO:1990698 palmitoleoyltransferase activity
Biological Process
GO:0006497 protein lipidation
GO:0009100 glycoprotein metabolic process
GO:0016055 Wnt signaling pathway
GO:0030258 lipid modification
GO:0045234 protein palmitoleylation
GO:0061355 Wnt protein secretion
GO:0099072 regulation of postsynaptic membrane neurotransmitter receptor levels
Cellular Component
GO:0005783 endoplasmic reticulum
GO:0005789 endoplasmic reticulum membrane
GO:0016020 membrane
GO:0032281 AMPA glutamate receptor complex
GO:0098978 glutamatergic synapse

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:7ura, PDBe:7ura, PDBj:7ura
PDBsum7ura
PubMed35831507
UniProtQ9H237|PORCN_HUMAN Protein-serine O-palmitoleoyltransferase porcupine (Gene Name=PORCN)

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