Structure of PDB 7uhy Chain A Binding Site BS02

Receptor Information
>7uhy Chain A (length=771) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
KPDILWAPHHVDRFVVCDSELSLYHVESTVNSELKAGSLRLSEDSAATLL
SINSDTPYMKCVAWYLNYDPECLLAVGQANGRVVLTSLGQDHNSKFKDLI
GKEFVPKHARQCNTLAWNPLDSNWLAAGLDKHRADFSVLIWDICSTKPLY
ELGQNDACLSLCWLPRDQKLLLAGMHRNLAIFDLRNTSQKMFVNTKAVQG
VTVDPYFHDRVASFYEGQVAIWDLRKFEKPVLTLTEQPKPLTKVAWCPTR
TGLLATLTRDSNIIRLYDMQHTTIIERSVQPCDNYIASFAWHPTSQNRMI
VVTPNRTMSDFTVFERISLAWSPITSLMWACGRHLYECTEEENDNSLEKD
IATKMRLRALSRYGLDTEQVWRNHILAGNEDPQLKSLWYTLHFMKQYTED
MDQKSLVYAGIKSIVKSSLGMVESSRHNWSIQNLNEERILALQLCGWIKK
GTDVDVGPFLNSLVQEGEWERAAAVALFNLDIRRAIQILNEGASSELNLN
VVAMALSGYTDEKNSLWREMCSTLRLQLNNPYLCVMFAFLTSETGSYDGV
LYENKVAVRDRVAFACKFLSDTQLNRYIEKLTNEMKEAGNLEGILLTGLT
KDGVDLMESYVDRTGDVQTASYCMLQGSPLDVLKDERVQYWIENYRNLLD
AWRFWHKRAEFDIHRSKLDPSSKPLAQVFVSCNFCGKSISYSKVTSCPGC
RKPLPRCALCLINMGTPVSSKDKKLAQFNNWFTWCHNCRHGGHAGHMLSW
FRDHAECPVSACTCKCMQLDT
Ligand information
Ligand IDZN
InChIInChI=1S/Zn/q+2
InChIKeyPTFCDOFLOPIGGS-UHFFFAOYSA-N
SMILES
SoftwareSMILES
CACTVS 3.341[Zn++]
ACDLabs 10.04
OpenEye OEToolkits 1.5.0		[Zn+2]
FormulaZn
NameZINC ION
ChEMBLCHEMBL1236970
DrugBankDB14532
ZINC
PDB chain7uhy Chain A Residue 1002 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB7uhy Structure of the nutrient-sensing hub GATOR2.
Resolution3.66 Å
Binding residue
(original residue number in PDB)		C785 H835 H838
Binding residue
(residue number reindexed from 1)		C707 H743 H746
Annotation score4
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0005515 protein binding
GO:0046872 metal ion binding
Biological Process
GO:0031503 protein-containing complex localization
GO:0031669 cellular response to nutrient levels
GO:0032289 central nervous system myelin formation
GO:0034198 cellular response to amino acid starvation
GO:0048709 oligodendrocyte differentiation
GO:0070444 oligodendrocyte progenitor proliferation
GO:1904262 negative regulation of TORC1 signaling
GO:1904263 positive regulation of TORC1 signaling
Cellular Component
GO:0005654 nucleoplasm
GO:0005737 cytoplasm
GO:0005764 lysosome
GO:0005765 lysosomal membrane
GO:0005829 cytosol
GO:0016020 membrane
GO:0030054 cell junction
GO:0061700 GATOR2 complex

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Molecular Function
View graph for
Biological Process
View graph for
Cellular Component
External links
PDB RCSB:7uhy, PDBe:7uhy, PDBj:7uhy
PDBsum7uhy
PubMed35831510
UniProtQ9NXC5|MIOS_HUMAN GATOR2 complex protein MIOS (Gene Name=MIOS)

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