Structure of PDB 7ugw Chain A Binding Site BS02

Receptor Information
>7ugw Chain A (length=485) Species: 83332 (Mycobacterium tuberculosis H37Rv) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
IEPVDIEQEMQRSYIDYAMSVIVGRALPEVRDGLKPVHRRVLYAMFDSGF
RPDRSHAKSARSVAETMGNYHPHGDASIYDSLVRMAQPWSLRYPLVDGQG
NFGSPGNDPPAAMRFTEARLTPLAMEMLREIDEETVDFIPNYDGRVQEPT
VLPSRFPNLLANGSGGIAVGMATNIPPHNLRELADAVFWALENHDADEEE
TLAAVMGRVKGPDFPTAGLIVGSQGTADAYKTGRGSIRMRGVVEVEERGR
TSLVITELPYQVNHDNFITSIAEQVRDGKLAGISNIEDQSSDRVGLRIVI
EIKRDAVAKVVINNLYKHTQLQTSFGANMLAIVDGVPRTLRLDQLIRYYV
DHQLDVIVRRTTYRLRKANERAHILRGLVKALDALDEVIALIRASETVDI
ARAGLIELLDIDEIQAQAILDMQLRRLAALERQRIIDDLAKIEAEIADLE
DILAKPERQRGIVRDELAEIVDRHGDDRRTRIIAA
Ligand information
>7ugw Chain E (length=12) Species: 1208607 (Photorhabdus noenieputensis) [Search peptide sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
WTRTHDSFGRSD
Receptor-Ligand Complex Structure
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PDB7ugw Evybactin is a DNA gyrase inhibitor that selectively kills Mycobacterium tuberculosis.
Resolution3.0 Å
Binding residue
(original residue number in PDB)		E212 D350 V352 P353 R354 Y364
Binding residue
(residue number reindexed from 1)		E198 D334 V336 P337 R338 Y348
Enzymatic activity
Enzyme Commision number 5.6.2.2: DNA topoisomerase (ATP-hydrolyzing).
Gene Ontology
Molecular Function
GO:0003677 DNA binding
GO:0003918 DNA topoisomerase type II (double strand cut, ATP-hydrolyzing) activity
GO:0005524 ATP binding
Biological Process
GO:0006259 DNA metabolic process
GO:0006265 DNA topological change

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Molecular Function
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Biological Process
External links
PDB RCSB:7ugw, PDBe:7ugw, PDBj:7ugw
PDBsum7ugw
PubMed35996001
UniProtP9WG47|GYRA_MYCTU DNA gyrase subunit A (Gene Name=gyrA)

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