Structure of PDB 7ug9 Chain A Binding Site BS02

Receptor Information
>7ug9 Chain A (length=206) Species: 562 (Escherichia coli) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
IYDLHSHTTASDGCLTPEALVHRAVEMRVGTLAITDHDTTAAIAPAREEI
SRSGLALNLIPGVEISTVWENHEIHIVGLNIDITHPLMCEFLAQQTERWC
TIEQAIDVIHHSGGKAVLAHPGRYNLSAKWLKRLVAHFAEHHGDAMEVAQ
CQQSPNERTQLAALARQHHLWASQGSDFHQPCPWIELGRKLWLPAGVEGV
WQLWEQ
Ligand information
Ligand IDMN
InChIInChI=1S/Mn/q+2
InChIKeyWAEMQWOKJMHJLA-UHFFFAOYSA-N
SMILES
SoftwareSMILES
ACDLabs 10.04
OpenEye OEToolkits 1.5.0		[Mn+2]
CACTVS 3.341[Mn++]
FormulaMn
NameMANGANESE (II) ION
ChEMBL
DrugBankDB06757
ZINC
PDB chain7ug9 Chain A Residue 302 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
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PDB7ug9 Identification of a novel deFADding activity in human, yeast and bacterial 5' to 3' exoribonucleases.
Resolution1.69 Å
Binding residue
(original residue number in PDB)		H15 D20 H45 H257
Binding residue
(residue number reindexed from 1)		H7 D12 H37 H179
Annotation score1
Enzymatic activity
Enzyme Commision number 3.1.13.-
3.1.3.97: 3',5'-nucleoside bisphosphate phosphatase.
Gene Ontology
Molecular Function
GO:0000166 nucleotide binding
GO:0003824 catalytic activity
GO:0004527 exonuclease activity
GO:0004534 5'-3' RNA exonuclease activity
GO:0008252 nucleotidase activity
GO:0030145 manganese ion binding
GO:0035312 5'-3' DNA exonuclease activity
GO:0046872 metal ion binding
GO:0097657 3',5'-nucleotide bisphosphate phosphatase activity
Biological Process
GO:0000470 maturation of LSU-rRNA
GO:0000481 maturation of 5S rRNA
GO:0006259 DNA metabolic process
GO:0006364 rRNA processing
GO:0030490 maturation of SSU-rRNA

View graph for
Molecular Function
View graph for
Biological Process
External links
PDB RCSB:7ug9, PDBe:7ug9, PDBj:7ug9
PDBsum7ug9
PubMed35904778
UniProtP77766|RNM_ECOLI 5'-3' exoribonuclease Rnm (Gene Name=rnm)

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