Structure of PDB 7ufg Chain A Binding Site BS02

Receptor Information
>7ufg Chain A (length=1151) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
RALYFSGRGEQLRLRADLELPRDAFTLQVWLRAEGGQRSPAVITGLYDKC
SYISRDRGWVVGIHTISDQDNKDPRYFFSLKTDRARQVTTINAHRSYLPG
QWVYLAATYDGQFMKLYVNGAQVATSGEQVGGIFSPLTQKCKVLMLGGSA
LNHNYRGYIEHFSLWKVARTQREILSDMETHGAHTALPQLLLQENWDNVK
HAWSPMKDGSSPKVEFSNAHGFLLDTSLEPPLCGQTLCDNTEVIASYNQL
SSFRQPKVVRYRVVNLYEDDHKNPTVTREQVDFQHHQLAEAFKQYNISWE
LDVLEVSNSSLRRRLILANCKNILKLDGSTHLNIFFAKSSEEELAGVATW
PWDKEALMHLGGIVLNPSFYGMPGHTHTMIHAIGHSLGLYHVFRGISEIQ
SCSDPCMETEPSFETGDLCNDTNPAPKHKSCGDPGPGNDTCGFHSFFNTP
YNNFMSYADDDCTDSFTPNQVARMHCYLDLVYQGWQPSRKPAPVALAPQV
LGHVTLEWFPPIDGHFFERELGSACHLCLEGRILVQYASNASSPMPCSPS
GHWSPREAEGHPDVEQPCKSSVRTWSPNSCPEPQGCYLELEFLYPLVPES
LTIWVTFVSTDWDSSGAVNDIKLLAVSGKNISLGPQNVFCDVPLTIRLWD
VGEEVYGIQIYTLDEHLEIDAAMLTSTADTPLCLQCKPLKYKVVRDPPLQ
MDVASILHLNRKFVDMDLNLGSVYQYWVITISGTEESEPSPAVTYIHGSG
YCGDGIIQKDQGEQCDDMNKINGDGCSLFCRQEVSFNCIDEPSRCYFHDG
DGVCEEFEQKTSIKDCGVYTPQGFLDQWASNASVSHQDQQCPGWVIIGQP
AASQVCRTKVIDLSEGISQHAWYPCTISYPYSQLAQTTFWLRAYFSQPMV
AAAVIVHLVTDGTYYGDQKQETISVQLLDTKDQSHDLGLHVLSCRNNPLI
IPVVHDLSQPFYHSQAVRVSFSSPLVAISGVALRSFDNFDPVTLSSCQRG
ETYSPAEQSCVHFACEKTDCPELAVENAYLNCSSSDRYHGAQCTVSCRTG
YVLQIRRDDELIKSQTGPSVTVTCTEGKWNKQVACEPVDCSIPDHHQVYA
ASFSCPEGTTFGSQCSFQCRHPAQLKGNNSLLTCMEDGLWSFPEALCELM
C
Ligand information
Ligand IDZN
InChIInChI=1S/Zn/q+2
InChIKeyPTFCDOFLOPIGGS-UHFFFAOYSA-N
SMILES
SoftwareSMILES
CACTVS 3.341[Zn++]
ACDLabs 10.04
OpenEye OEToolkits 1.5.0		[Zn+2]
FormulaZn
NameZINC ION
ChEMBLCHEMBL1236970
DrugBankDB14532
ZINC
PDB chain7ufg Chain A Residue 4000 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
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PDB7ufg Structure of the PAPP-ABP5 complex reveals mechanism of substrate recognition
Resolution3.28 Å
Binding residue
(original residue number in PDB)		H482 H486 H492
Binding residue
(residue number reindexed from 1)		H381 H385 H391
Annotation score4
Enzymatic activity
Enzyme Commision number 3.4.24.79: pappalysin-1.
Gene Ontology
Molecular Function
GO:0004175 endopeptidase activity
GO:0004222 metalloendopeptidase activity
GO:0005515 protein binding
GO:0008237 metallopeptidase activity
GO:0008270 zinc ion binding
GO:0046872 metal ion binding
Biological Process
GO:0006508 proteolysis
GO:0007166 cell surface receptor signaling pathway
GO:0007565 female pregnancy
GO:0030163 protein catabolic process
GO:0032354 response to follicle-stimulating hormone
GO:0071548 response to dexamethasone
Cellular Component
GO:0005576 extracellular region
GO:0005615 extracellular space

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Molecular Function
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Biological Process
View graph for
Cellular Component
External links
PDB RCSB:7ufg, PDBe:7ufg, PDBj:7ufg
PDBsum7ufg
PubMed36127359
UniProtQ13219|PAPP1_HUMAN Pappalysin-1 (Gene Name=PAPPA)

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