Structure of PDB 7u76 Chain A Binding Site BS02

Receptor Information
>7u76 Chain A (length=430) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
GPHMATGQDRVVALVDMDCFFVQVEQRQNPHLRNKPCAVVQYKSWKGGGI
IAVSYEARAFGVTRSMWADDAKKLCPDLLLAQVRESRGKANLTKYREASV
EVMEIMSRFAVIERASIDEAYVDLTSAVQERLQKLQGQPISADLLPSTYI
EGLPQGPTVQKEGMRKQGLFQWLDSLQIDNLTSPDLQLTVGAVIVEEMRA
AIERETGFQCSAGISHNKVLAKLACGLNKPNRQTLVSHGSVPQLFSQMPI
RKIRSLGGKLGASVIEILGIEYMGELTQFTESQLQSHFGEKNGSWLYAMC
RGIEHDPVKPRQLPKTIGCSKNFPGKTALATREQVQWWLLQLAQELEERL
TKDRNDNDRVATQLVVSIRVQGDKRLSSLRRCCALTRYDAHKMSHDAFTV
IKNCNTSGIQTEWSPPLTMLFLCATKFSAS
Ligand information
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB7u76 In crystallo observation of three metal ion promoted DNA polymerase misincorporation.
Resolution1.69 Å
Binding residue
(original residue number in PDB)		D13 F17 F18 Q38 I48 R61 D115 E116 K224 S257 G259 G260 K261 L262 R377 L381 R382 C384
Binding residue
(residue number reindexed from 1)		D16 F20 F21 Q41 I51 R64 D118 E119 K222 S255 G257 G258 K259 L260 R375 L379 R380 C382
Enzymatic activity
Enzyme Commision number 2.7.7.7: DNA-directed DNA polymerase.
Gene Ontology
Molecular Function
GO:0003684 damaged DNA binding
Biological Process
GO:0006281 DNA repair

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Molecular Function
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Biological Process
External links
PDB RCSB:7u76, PDBe:7u76, PDBj:7u76
PDBsum7u76
PubMed35487947
UniProtQ9Y253|POLH_HUMAN DNA polymerase eta (Gene Name=POLH)

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