Structure of PDB 7u1y Chain A Binding Site BS02

Receptor Information
>7u1y Chain A (length=439) Species: 4896 (Schizosaccharomyces pombe) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
SMKFLNPPFPYSMTSDPESFGHECFTRRWGIILTGIEKDVSERLSKLAST
SKDSEVVAQGKPLLNDLEAFKSDIKNDRPLVPLEGEGQDIVEYNEELKQL
DNASWGNAPWLYSECYYYRRISLIFARYSEWKAYDPFFQQKDSTLKSSRA
AVEELAGRYCLLEEELNSIAKKGDSHIAYMVFVEMAQISLWGNATDLSLL
TNLSYEELQNLQGQKVVEESQKNILVNDFPTVWSKLKDVHNGRIDFVLDN
AGFELYVDLIFAAYLLKAGIAKEIVLHPKDFPWFVSDVLPYDIEYLLTNL
DTIFPTESVTKFATDLRSFSAKGQLRLRTDPFWTTAHYFGRMPDFAAGLL
TELEKSDMIFFKGDLNYRKLTGDCLWPRTTPFGKTLGPIANAINACALRT
CKADVVVGLPDGLYEKIAKDLPHWERTGKYAVVEFCPKA
Ligand information
Ligand IDFRU
InChIInChI=1S/C6H12O6/c7-1-3-4(9)5(10)6(11,2-8)12-3/h3-5,7-11H,1-2H2/t3-,4-,5+,6-/m1/s1
InChIKeyRFSUNEUAIZKAJO-ARQDHWQXSA-N
SMILES
SoftwareSMILES
ACDLabs 10.04OC1C(O)C(OC1(O)CO)CO
OpenEye OEToolkits 1.5.0C([C@@H]1[C@H]([C@@H]([C@](O1)(CO)O)O)O)O
CACTVS 3.341OC[CH]1O[C](O)(CO)[CH](O)[CH]1O
OpenEye OEToolkits 1.5.0C(C1C(C(C(O1)(CO)O)O)O)O
CACTVS 3.341OC[C@H]1O[C@](O)(CO)[C@@H](O)[C@@H]1O
FormulaC6 H12 O6
Namebeta-D-fructofuranose;
beta-D-fructose;
D-fructose;
fructose
ChEMBLCHEMBL604608
DrugBank
ZINCZINC000001529270
PDB chain7u1y Chain B Residue 2 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
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PDB7u1y Fission yeast Duf89 and Duf8901 are cobalt/nickel-dependent phosphatase-pyrophosphatases that act via a covalent aspartyl-phosphate intermediate.
Resolution1.81 Å
Binding residue
(original residue number in PDB)		S40 L63
Binding residue
(residue number reindexed from 1)		S41 L64
Annotation score5
Enzymatic activity
Enzyme Commision number 3.1.3.-
Gene Ontology
Molecular Function
GO:0004427 inorganic diphosphate phosphatase activity
GO:0016787 hydrolase activity
GO:0016791 phosphatase activity
GO:0046872 metal ion binding
GO:0097023 fructose 6-phosphate aldolase activity
GO:0103026 fructose-1-phosphatase activity
Biological Process
GO:0006974 DNA damage response
GO:0030643 intracellular phosphate ion homeostasis
GO:1990748 cellular detoxification
Cellular Component
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0005829 cytosol

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:7u1y, PDBe:7u1y, PDBj:7u1y
PDBsum7u1y
PubMed35314193
UniProtQ9UT55|ART1A_SCHPO Damage-control phosphatase SPAC806.04c (Gene Name=SPAC806.04c)

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