Structure of PDB 7u1p Chain A Binding Site BS02

Receptor Information
>7u1p Chain A (length=617) Species: 4932 (Saccharomyces cerevisiae) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
SFPEGKPNCLLGLTIVFTGVLPTLERGASEALAKRYGARVTKSISSKTSV
VVLGDEAGPKKLEKIKQLKIKAIDEEGFKQLIAGMPAEGDGEAAEKARRK
LEEQHNIATKEAELLVKKEEERSKKLAAVVREEDKLWTVKYAPTNLQQVC
GNKGSVMKLKNWLANWENSKKNSFKHAGKDGSGVFRAAMLYGPPGIGKTT
AAHLVAQELGYDILEQNASDVRSKTLLNAGVKNALDNMSVVGYFKHNEEA
QNLNGKHFVIIMDEVDGMSGGDRGGVGQLAQFCRKTSTPLILICNERNLP
KMRPFDRVCLDIQFRRPDANSIKSRLMTIAIREKFKLDPNVIDRLIQTTR
GDIRQVINLLSTISTTTKTINHENINEISKAWEKNIALKPFDIAHKMLDG
QIYSDIGSRNFTLNDKIALYFDDFDFTPLMIQENYLSTRPSVLKPGQSHL
EAVAEAANCISLGDIVEKKIRSSEQLWSLLPLHAVLSSVYPASKVAGHMA
GRINFTAWLGQNSKSAKYYRLLQEIHYHTRLGTSTDKIGLRLDYLPTFRK
RLLDPFLKQGADAISSVIEVMDDYYLTKEDWDSIMEFFVGPDVTTAIIKK
IPATVKSGFTRKYNSMT
Ligand information
Receptor-Ligand Complex Structure
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PDB7u1p A second DNA binding site on RFC facilitates clamp loading at gapped or nicked DNA.
Resolution3.0 Å
Binding residue
(original residue number in PDB)		T189 S193 S194 K195 R383 S384 K385 T386 N459 Q474 R476 R477 P551 F552 F587 R632 S633 S634 Q636 W638 F666 L670
Binding residue
(residue number reindexed from 1)		T41 S45 S46 K47 R222 S223 K224 T225 N298 Q313 R315 R316 P390 F391 F426 R471 S472 S473 Q475 W477 F505 L509
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0003677 DNA binding
GO:0003689 DNA clamp loader activity
GO:0005515 protein binding
GO:0005524 ATP binding
GO:0016887 ATP hydrolysis activity
Biological Process
GO:0000278 mitotic cell cycle
GO:0006260 DNA replication
GO:0006261 DNA-templated DNA replication
GO:0006271 DNA strand elongation involved in DNA replication
GO:0006272 leading strand elongation
GO:0006281 DNA repair
GO:0006298 mismatch repair
GO:0051301 cell division
Cellular Component
GO:0005634 nucleus
GO:0005663 DNA replication factor C complex

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:7u1p, PDBe:7u1p, PDBj:7u1p
PDBsum7u1p
PubMed35731107
UniProtP38630|RFC1_YEAST Replication factor C subunit 1 (Gene Name=RFC1)

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