Structure of PDB 7tx8 Chain A Binding Site BS02

Receptor Information
>7tx8 Chain A (length=295) Species: 43151 (Anopheles darlingi) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
RWTALTPEETLFIYTRCQEEHLPADNNSRKTYIENWHQWKLQPNDHVTQC
YTKCVLEGLELYDGKQKKFRPGRVSSQHVAYQFLNGATADEVAKYKGAID
ALEPASDSCEDLYMAYFPVHETFVNVTRKLYHGTVEGAARVYNSDPNLKR
KNESLFTYCEKHVYGDQNREDMCRGRRYELTGSDELRNMIECVFRGLRYI
KHGDINIDEIVRDFDHINRGDLEPRVRTILSDCRGIQPYDYYSCLINSDI
REEFKLAFDYRDVRSADYAYIVKGNTYDAQKVIAEMNKVEKHVCG
Ligand information
Ligand IDPUC
InChIInChI=1S/C21H34O4/c1-2-3-6-9-17(22)12-13-19-18(16-14-20(19)25-15-16)10-7-4-5-8-11-21(23)24/h4,7,12-13,16-20,22H,2-3,5-6,8-11,14-15H2,1H3,(H,23,24)/b7-4-,13-12+/t16-,17+,18+,19-,20-/m1/s1
InChIKeyLQANGKSBLPMBTJ-BRSNVKEHSA-N
SMILES
SoftwareSMILES
OpenEye OEToolkits 1.7.0CCCCCC(C=CC1C2CC(C1CC=CCCCC(=O)O)CO2)O
OpenEye OEToolkits 1.7.0CCCCC[C@@H](/C=C/[C@H]1[C@H]2C[C@@H]([C@@H]1C/C=C\CCCC(=O)O)CO2)O
CACTVS 3.352CCCCC[CH](O)C=C[CH]1[CH]2C[CH](CO2)[CH]1CC=CCCCC(O)=O
CACTVS 3.352CCCCC[C@H](O)/C=C/[C@H]1[C@H]2C[C@H](CO2)[C@@H]1C\C=C/CCCC(O)=O
FormulaC21 H34 O4
Name(5Z)-7-{(1R,4S,5S,6R)-6-[(1E,3S)-3-hydroxyoct-1-en-1-yl]-2-oxabicyclo[2.2.1]hept-5-yl}hept-5-enoic acid;
15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid
ChEMBLCHEMBL521784
DrugBank
ZINCZINC000008716754
PDB chain7tx8 Chain A Residue 402 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
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PDB7tx8 Functional aspects of evolution in a cluster of salivary protein genes from mosquitoes.
Resolution2.51 Å
Binding residue
(original residue number in PDB)		Y16 W38 W41 Y53 V57 G135 T136 K153
Binding residue
(residue number reindexed from 1)		Y14 W36 W39 Y51 V55 G133 T134 K151
Annotation score1
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0005549 odorant binding
GO:0090729 toxin activity
Biological Process
GO:0035821 modulation of process of another organism
Cellular Component
GO:0005576 extracellular region

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:7tx8, PDBe:7tx8, PDBj:7tx8
PDBsum7tx8
PubMed35568118
UniProtB6DDQ8|D7L2_ANODA Long form salivary protein D7L2 (Gene Name=D7L2)

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