Structure of PDB 7tuv Chain A Binding Site BS02

Receptor Information
>7tuv Chain A (length=672) Species: 5691 (Trypanosoma brucei) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
ALFSPHLAESALDLGVQNGTYLRGKLRVSETNCFFGEIRGQWKGHNFERV
LLPGRTNLNRAIHGDIVTVELLPVASWRPLREESEGAALARGYTPVGRVV
GITTMNRRPFCGSIDVEELNKLALTGTVSVLFQPKDNRIPRIRITTAHLG
DLKDKRLSVIIDDWGEHSSFPVGHYVEVLGTIGDKDTEAKVILLENDIPH
YDFSEAVYDCLPKGEWNVTEEELGNRLDLRDLCVVSVDPLGCRDIDDALH
CRRVNGNHLEVGVHIADVTHFLKEGTAMDEEAAKRSTSVYLVDRRINMLP
QLLTENLCSIVADEDRYAFSIMWEFDENYSVVREFFGKTVIRSRAALYYG
DAQRMIDDPEDESEAAVSLRYLMQLSRHFRKRREKDGALFLCSQEFKFKV
DNDHVNPTDMQAYQTFDSNSMIEEWMLFANAAAARRVYASFPRWTLLRRH
QAPAENAFDTLNEAIRRKIGVKLDDTTSLALNESLEKCVDPSDPYFNRLI
RTLVTRCLRQAQYFSSSEVSKDEFHHFGLAMPIYTHFTSPIRRYADVIVH
RQLAAALGIMDVSEHMVSVKMEALASNLNYRHEQAQKAGRDSQNLFTGFY
LRNFANQEIPSEDGYVVKLSETHVFVLVPKYGQEGKIAKETLVRVPNLLD
KVKVGIEVRASLVFSIIGLMKG
Ligand information
Ligand IDU5P
InChIInChI=1S/C9H13N2O9P/c12-5-1-2-11(9(15)10-5)8-7(14)6(13)4(20-8)3-19-21(16,17)18/h1-2,4,6-8,13-14H,3H2,(H,10,12,15)(H2,16,17,18)/t4-,6-,7-,8-/m1/s1
InChIKeyDJJCXFVJDGTHFX-XVFCMESISA-N
SMILES
SoftwareSMILES
ACDLabs 10.04O=C1NC(=O)N(C=C1)C2OC(C(O)C2O)COP(=O)(O)O
CACTVS 3.341O[CH]1[CH](O)[CH](O[CH]1CO[P](O)(O)=O)N2C=CC(=O)NC2=O
OpenEye OEToolkits 1.5.0C1=CN(C(=O)NC1=O)[C@H]2[C@@H]([C@@H]([C@H](O2)COP(=O)(O)O)O)O
OpenEye OEToolkits 1.5.0C1=CN(C(=O)NC1=O)C2C(C(C(O2)COP(=O)(O)O)O)O
CACTVS 3.341O[C@H]1[C@@H](O)[C@@H](O[C@@H]1CO[P](O)(O)=O)N2C=CC(=O)NC2=O
FormulaC9 H13 N2 O9 P
NameURIDINE-5'-MONOPHOSPHATE
ChEMBLCHEMBL214393
DrugBankDB03685
ZINCZINC000002123545
PDB chain7tuv Chain A Residue 1001 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB7tuv Trypanosoma brucei RRP44: a versatile enzyme for processing structured and non-structured RNA substrates.
Resolution2.225 Å
Binding residue
(original residue number in PDB)		P504 C507 D509 Y555 R807
Binding residue
(residue number reindexed from 1)		P239 C242 D244 Y290 R542
Annotation score4
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0003723 RNA binding
GO:0004540 RNA nuclease activity

View graph for
Molecular Function
External links
PDB RCSB:7tuv, PDBe:7tuv, PDBj:7tuv
PDBsum7tuv
PubMed36583334
UniProtQ95Z12

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