Structure of PDB 7tqw Chain A Binding Site BS02

Receptor Information

>7tqw Chain A (length=756) Species: 311400 (Thermococcus kodakarensis)

MILDTDYITEDGKPVIRIFKKENGEFKIEYDRTFEPYFYALLKDDSAIEE
VKKITAERHGTVVTVKRVEKVQKKFLGRPVEVWKLYFTHPQDVPAIRDKI
REHPAVIDIYEYDIPFAKRYLIDKGLVPMEGDEELKMLAFDIETLYHEGE
EFAEGPILMISYADEEGARVITWKNVDLPYVDVVSTEREMIKRFLRVVKE
KDPDVLITYNGDNFDFAYLKKRCEKLGINFALGRDGSEPKIQRMGDRFAV
EVKGRIHFDLYPVIRRTINLPTYTLEAVYEAVFGQPKEKVYAEEITTAWE
TGENLERVARYSMEDAKVTYELGKEFLPMEAQLSRLIGQSLWDVSRSSTG
NLVEWFLLRKAYERNELAPNKPDEKELARRRQSYEGGYVKEPERGLWENI
VYLDFRSLYPSIIITHNVSPDTLNREGCKEYDVAPQVGHRFCKDFPGFIP
SLLGDLLEERQKIKKKMKATIDPIERKLLDYRQRRIKILASSYYGYYGYA
RARWYCKECAESVTAWGREYITMTIKEIEEKYGFKVIYSDTDGFFATIPG
ADAETVKKKAMEFLKYINAKLPGALELEYEGFYKRGFFVTKKKYAVIDEE
GKITTGGLEIVRRDWSEIAKETQARVLEALLKDGDVEKAVRIVKEVTEKL
SKYEVPPEKLVIHEQITRDLKDYKATGPHVAVAKRLAARGVKIRPGTVIS
YIVLKGSGRIGDRAIPFDEFDPAKHKYDAEYYIENQVLPAVERILRAFGY
RKEDLR

Ligand information

>7tqw Chain P (length=13)

cgcgaactgcgaa

Receptor-Ligand Complex Structure

Structure summary

• PDB: 7tqw Crystallographic analysis of engineered polymerases synthesizing phosphonomethylthreosyl nucleic acid.
• Resolution: 3.01 Å
• Binding residue (original residue number in PDB): N269 D540 T541 D542 K592 Y594 G607 V611 R612 R613 Q665 T667 R668 Y673 H679
• Binding residue (residue number reindexed from 1): N269 D540 T541 D542 K592 Y594 G607 V611 R612 R613 Q665 T667 R668 Y673 H679

Enzymatic activity

• Enzyme Commision number: 2.7.7.7: DNA-directed DNA polymerase.

Gene Ontology

Molecular Function

• GO:0000166 nucleotide binding
• GO:0003676 nucleic acid binding
• GO:0003677 DNA binding
• GO:0003887 DNA-directed DNA polymerase activity
• GO:0046872 metal ion binding

Biological Process

• GO:0006260 DNA replication
• GO:0071897 DNA biosynthetic process

External links

• PDB: RCSB:7tqw, PDBe:7tqw, PDBj:7tqw
• PDBsum: 7tqw
• PubMed: 36124684
• UniProt: D0VWU9