Structure of PDB 7tom Chain A Binding Site BS02

Receptor Information
>7tom Chain A (length=498) Species: 2190 (Methanocaldococcus jannaschii) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
GSHMEKKTLSLCPICLKRIPATILEEDGKIIIKKTCPEHGEFKDIYWGDA
ELYKKFDKYEFIGKIEVTNTKVKNGCPYDCGLCPNHKSTTILANIDVTNR
CNLNCPICFANANKSGKVYEPSFEDIKRMMENLRKEIPPTPAIQFAGGEP
TVRSDLPELIKLARDMGFLHVQLATNGIKLKNINYLKKLKEAGLSTIYLQ
FDGISEKPYLVARGKNLLPIKQKVIENCKKVGFDSVVLVPTLVRGVNDNE
VGGIIRYAAENVDVVRGINFQPVSFTGRVDEKTLLEGRITIPDFIKLVEE
QTDGEITEEDFYPVPSVAPISVLVEKLTNDRKPTLSSHQHCGTSTYVFVD
EDGKLIPITRFIDVEGFLEIVKEKIEEIDVKVLGEIALKLPSLIDLDKAP
KSVNIKKIIDLILSVLKSDYSALAELHYHMLMISCMHFMDAYNFDVKRVM
RCCIHYATPDDRIIPFCTYNTLHRQEVEEKFSIPLEEWKRMHKIGGED
Ligand information
Ligand IDSF4
InChIInChI=1S/4Fe.4S
InChIKeyLJBDFODJNLIPKO-UHFFFAOYSA-N
SMILES
SoftwareSMILES
OpenEye OEToolkits 2.0.7[S]12[Fe]3[S]4[Fe]1[S]5[Fe]2[S]3[Fe]45
CACTVS 3.385S1[Fe]S[Fe]1.S2[Fe]S[Fe]2
FormulaFe4 S4
NameIRON/SULFUR CLUSTER
ChEMBL
DrugBank
ZINC
PDB chain7tom Chain A Residue 602 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
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PDB7tom Discovery, structure and mechanism of a tetraether lipid synthase.
Resolution1.85 Å
Binding residue
(original residue number in PDB)		C98 C102 C105 A109 G145 N173 Q197
Binding residue
(residue number reindexed from 1)		C101 C105 C108 A112 G148 N176 Q200
Annotation score4
Enzymatic activity
Enzyme Commision number 2.1.1.-
Gene Ontology
Molecular Function
GO:0003824 catalytic activity
GO:0008168 methyltransferase activity
GO:0046872 metal ion binding
GO:0051536 iron-sulfur cluster binding
GO:0051539 4 iron, 4 sulfur cluster binding
Biological Process
GO:0032259 methylation

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Molecular Function
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Biological Process
External links
PDB RCSB:7tom, PDBe:7tom, PDBj:7tom
PDBsum7tom
PubMed35882349
UniProtQ58036|HMPTM_METJA 7,8-dihydro-6-hydroxymethylpterin dimethyltransferase (Gene Name=MJ0619)

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