Structure of PDB 7tmp Chain A Binding Site BS02

Receptor Information
>7tmp Chain A (length=593) Species: 4932 (Saccharomyces cerevisiae) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
YGAIYSVSGPVVIAENMIGCAMYELVKVGHDNLVGEVIRIDGDKATIQVY
EETAGLTVGDPVLRTGKPLSVELGPGLMETIYDGIQRPLKAIKEESQSIY
IPRGIDTPALDRTIKWQFTPGKFQVGDHISGGDIYGSVFENSLISSHKIL
LPPRSRGTITWIAPAGEYTLDEKILEVEFDGKKSDFTLYHTWPVRVPRPV
TEKLSADYPLLTGQRVLDALFPCVQGGTTCIPGAFGCGKTVISQSLSKYS
NSDAIIYVGCGERGNEMAEVLMEFPELYTEMSGTKEPIMKRTTLVANTSN
MPVAAREASIYTGITLAEYFRDQGKNVSMIADSSSRWAEALREISGRLGE
MPADQGFPAYLGAKLASFYERAGKAVALGSPDRTGSVSIVAAVSPAGGDF
SDPVTTATLGITQVFWGLDKKLAQRKHFPSINTSVSYSKYTNVLNKFYDS
NYPEFPVLRDRMKEILSNAEELEQVVQLVGKSALSDSDKITLDVATLIKE
DFLQQNGYSTYDAFCPIWKTFDMMRAFISYHDEAQKAVANGANWSKLADS
TGDVKHAVSSSKFFEPSRGEKEVHGEFEKLLSTMQERFAESTD
Ligand information
Ligand IDMG
InChIInChI=1S/Mg/q+2
InChIKeyJLVVSXFLKOJNIY-UHFFFAOYSA-N
SMILES
SoftwareSMILES
ACDLabs 10.04
OpenEye OEToolkits 1.5.0		[Mg+2]
CACTVS 3.341[Mg++]
FormulaMg
NameMAGNESIUM ION
ChEMBL
DrugBankDB01378
ZINC
PDB chain7tmp Chain A Residue 702 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
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PDB7tmp Coordinated conformational changes in the V 1 complex during V-ATPase reversible dissociation.
Resolution3.3 Å
Binding residue
(original residue number in PDB)		T263 E289
Binding residue
(residue number reindexed from 1)		T240 E266
Annotation score1
Enzymatic activity
Enzyme Commision number 3.1.-.-
7.1.2.2: H(+)-transporting two-sector ATPase.
Gene Ontology
Molecular Function
GO:0005524 ATP binding
GO:0016887 ATP hydrolysis activity
GO:0046961 proton-transporting ATPase activity, rotational mechanism
Biological Process
GO:0046034 ATP metabolic process
GO:1902600 proton transmembrane transport
Cellular Component
GO:0033180 proton-transporting V-type ATPase, V1 domain

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:7tmp, PDBe:7tmp, PDBj:7tmp
PDBsum7tmp
PubMed35469063
UniProtP17255|VATA_YEAST V-type proton ATPase catalytic subunit A (Gene Name=VMA1)

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