Structure of PDB 7tji Chain A Binding Site BS02

Receptor Information
>7tji Chain A (length=485) Species: 4932 (Saccharomyces cerevisiae) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
VIRKFTKKNVARAKKKYTPFSKRFKSIAAIPDLTSLPEFYGNSRFENKLK
TTQKHQIVETIFSKVKKQLNSSLPARENEFASIYLSAYSAIESDSATTIY
VAGTPGVGKTLTVREVVKELLSSSAQREIPDFLYVEINGLKMVKPTDCYE
TLWNKVSGERLTWAASMESLEFYFKRVPKNKKKTIVVLLDELDAMVTKSQ
DIMYNFFNWTTYENAKLIVIAVANTMDLPERQLGNKITSRIGFTRIMFTG
YTHEELKNIIDLRLKGLNDSFFYVDTKTGNAILIDVRKVRLRMSADAIEI
ASRKVASVSGDARRALKVCKRAAEIAEKHYMAKHGYGYDGVQTVHITHVM
KALNETLNSHVITFMTRLSFTAKLFIYALLNLMKKNGSQEQELGDIVDEI
KLLIEVNGSNKFVMEIAKTLFQQGSDNISEQLRIISWDFVLNQLLDAGIL
FKQTMKNDRICCVKLNISVEEAKRAMNEDETLRNL
Ligand information
>7tji Chain H (length=41) [Search DNA sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
tttgaaaagcaagcataaaagatctaaacataaaatctgta
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

[Spin on] [Spin off] [Reset]
[High quality] [Low quality]
[White background] [Black background]
[Spin on] [Spin off] [Reset]
[High quality] [Low quality]
[White background] [Black background]
PDB7tji A mechanism of origin licensing control through autoinhibition of S. cerevisiae ORC·DNA·Cdc6.
Resolution2.7 Å
Binding residue
(original residue number in PDB)		R358 K359 F360 K362 R367 K369 K370 K371 Y372 T373
Binding residue
(residue number reindexed from 1)		R3 K4 F5 K7 R12 K14 K15 K16 Y17 T18
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0003677 DNA binding
GO:0003682 chromatin binding
GO:0003688 DNA replication origin binding
GO:0005515 protein binding
GO:0005524 ATP binding
GO:0016887 ATP hydrolysis activity
GO:0031491 nucleosome binding
GO:0046872 metal ion binding
Biological Process
GO:0006260 DNA replication
GO:0006267 pre-replicative complex assembly involved in nuclear cell cycle DNA replication
GO:0006270 DNA replication initiation
GO:0030466 silent mating-type cassette heterochromatin formation
GO:0033314 mitotic DNA replication checkpoint signaling
GO:0034728 nucleosome organization
GO:0043007 maintenance of rDNA
Cellular Component
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005656 nuclear pre-replicative complex
GO:0005664 nuclear origin of replication recognition complex
GO:0005694 chromosome
GO:0031261 DNA replication preinitiation complex
GO:0032993 protein-DNA complex

View graph for
Molecular Function
View graph for
Biological Process
View graph for
Cellular Component
External links
PDB RCSB:7tji, PDBe:7tji, PDBj:7tji
PDBsum7tji
PubMed35217664
UniProtP54784|ORC1_YEAST Origin recognition complex subunit 1 (Gene Name=ORC1)

[Back to BioLiP]