Structure of PDB 7tf6 Chain A Binding Site BS02

Receptor Information

>7tf6 Chain A (length=438) Species: 1280 (Staphylococcus aureus) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]

TFTKEDIRKFAEEENVRYLRLQFTDILGTIKNVEVPVSQLEKVLDNEMMF
DGSSIEGFVRIEESDMYLHPDLDTWVIFPWGKVARLICDVYKTDGTPFEG
DPRANLKRVLKEMEDLGFTDFNLGPEPEFFLFKLDEKGEPTLELNDDGGY
FDLAPTDLGENCRRDIVLELEDMGFDIEASHHEVAPGQHEIDFKYADAVT
ACDNIQTFKLVVKTIARKHNLHATFMPKPLFGVNGSGMHFNVSLFKGKEN
AFFDPNTEMGLTETAYQFTAGVLKNARGFTAVCNPLVNSYKRLVPGYEAP
CYIAWSGKNRSPLIRVPSSRGLSTRIEVRSVDPAANPYMALAAILEAGLD
GIKNKLKVPEPVNQNIYEMNREEREAVGIQDLPSTLYTALKAMRENEVIK
KALGNHIYNQFINSKSIEWDYYRTQVSEWERDQYMKQY

Ligand information

>7tf6 Chain U (length=11) Species: 1280 (Staphylococcus aureus) [Search peptide sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]

PINRGDLSRFI

Receptor-Ligand Complex Structure

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Structure summary

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PDB	7tf6 Molecular dissection of the glutamine synthetase-GlnR nitrogen regulatory circuitry in Gram-positive bacteria.
Resolution	2.15 Å
Binding residue (original residue number in PDB)	G240 N242 G304 Y305 R318 Y375
Binding residue (residue number reindexed from 1)	G232 N234 G296 Y297 R310 Y367

Enzymatic activity

Enzyme Commision number

6.3.1.2: glutamine synthetase.

Gene Ontology

	Molecular Function
GO:0003824	catalytic activity
GO:0004356	glutamine synthetase activity
GO:0005524	ATP binding
GO:0016874	ligase activity
GO:0046872	metal ion binding

	Biological Process
GO:0006542	glutamine biosynthetic process

	Cellular Component
GO:0005737	cytoplasm

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Molecular Function

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Biological Process

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Cellular Component

External links

PDB	RCSB:7tf6, PDBe:7tf6, PDBj:7tf6
PDBsum	7tf6
PubMed	35778410
UniProt	E3VXC2

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