Structure of PDB 7td5 Chain A Binding Site BS02

Receptor Information
>7td5 Chain A (length=497) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
SEYMRLRQLKRLQANMGAKALYVANFAKVQEKTQILNEEWKKLRVQPVQS
MLKKCTIESIFPGFASQHMLMRSLNTVALVPIMYSWSPLQQNFMVEDETV
LCNIPYMGDEVKEEDETFIEELINNYDGKVHGEEQCTPNIDGPNAKSVQR
EQSLHSFHTLFCRRCFKYDCFLHPFHATPNVYKRKNKEIKIEPEPCGTDC
FLLLEGAKEYAMLHNVEAPSPVEWTGAEESLFRVFHGTYFNNFCSIARLL
GTKTCKQVFQFAVKESLILSTQVYNYQPCDHPDRPCDSTCPCIMTQNFCE
KFCQCNPDCQNRFPGCRCKTQCNTKQCPCYLAVRECDPDLCLTCGASEHW
DCKVVSCKNCSIQRGLKKHLLLAPSDVAGWGTFIKESVQKNEFISEYCGE
LISQDEADRRGKVYDKYMSSFLFNLNNDFVVDATRKGNKIRFANHSVNPN
CYAKVVMVNGDHRIGIFAKRAIQAGEELFFDYRYSQADALKYVGIER
Ligand information
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB7td5 CK2-mediated phosphorylation of SUZ12 promotes PRC2 function by stabilizing enzyme active site.
Resolution2.994 Å
Binding residue
(original residue number in PDB)		Y134 D137 E161
Binding residue
(residue number reindexed from 1)		Y106 D109 E133
Enzymatic activity
Enzyme Commision number 2.1.1.356: [histone H3]-lysine(27) N-trimethyltransferase.
Gene Ontology
Molecular Function
GO:0003677 DNA binding
GO:0003682 chromatin binding
GO:0003714 transcription corepressor activity
GO:0005515 protein binding
GO:0008168 methyltransferase activity
GO:0031491 nucleosome binding
GO:0042054 histone methyltransferase activity
GO:0042393 histone binding
GO:0046976 histone H3K27 methyltransferase activity
GO:0140693 molecular condensate scaffold activity
GO:0140951 histone H3K27 trimethyltransferase activity
Biological Process
GO:0000122 negative regulation of transcription by RNA polymerase II
GO:0006325 chromatin organization
GO:0006338 chromatin remodeling
GO:0009653 anatomical structure morphogenesis
GO:0021766 hippocampus development
GO:0031507 heterochromatin formation
GO:0031509 subtelomeric heterochromatin formation
GO:0032259 methylation
GO:0045944 positive regulation of transcription by RNA polymerase II
Cellular Component
GO:0000781 chromosome, telomeric region
GO:0000792 heterochromatin
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0035098 ESC/E(Z) complex

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:7td5, PDBe:7td5, PDBj:7td5
PDBsum7td5
PubMed36351927
UniProtQ92800|EZH1_HUMAN Histone-lysine N-methyltransferase EZH1 (Gene Name=EZH1)

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