Structure of PDB 7t92 Chain A Binding Site BS02

Receptor Information
>7t92 Chain A (length=298) Species: 573729 (Thermothelomyces thermophilus ATCC 42464) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
TRPAFRVGQVDAELLDEELVELLRGQVREALRYVGGGGSGVAQDWEAEIS
LALRAVLFKLTVWDHDATYGAALQNLKYTDARRDGPALAPPSRWQKALYG
LVTVGGRYLWAKWEDWLLEQDDPSPRVKRLARWTSSLSTLHASAALVSFL
VFLLHGRYRTLLDRLLRMRLAPPTSQVSFEYLNRQLVWHAFTEFLLFVLP
LVGINRWRRWLARTWRDKKGEYSFLPERTCAICYRDQNSVVGSAQTDITN
PYEAIPCGCTYCFVCLATRIEREEGEGWPCLRCGELIKECKPWNGDVL
Ligand information
Ligand IDZN
InChIInChI=1S/Zn/q+2
InChIKeyPTFCDOFLOPIGGS-UHFFFAOYSA-N
SMILES
SoftwareSMILES
CACTVS 3.341[Zn++]
ACDLabs 10.04
OpenEye OEToolkits 1.5.0		[Zn+2]
FormulaZn
NameZINC ION
ChEMBLCHEMBL1236970
DrugBankDB14532
ZINC
PDB chain7t92 Chain A Residue 402 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
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PDB7t92 A peroxisomal ubiquitin ligase complex forms a retrotranslocation channel.
Resolution3.1 Å
Binding residue
(original residue number in PDB)		C270 C316 C319
Binding residue
(residue number reindexed from 1)		C230 C262 C265
Annotation score4
Enzymatic activity
Enzyme Commision number 2.3.2.36: RING-type E3 ubiquitin transferase (cysteine targeting).
Gene Ontology
Molecular Function
GO:0008270 zinc ion binding
Biological Process
GO:0007031 peroxisome organization
GO:0016558 protein import into peroxisome matrix
Cellular Component
GO:0005778 peroxisomal membrane

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:7t92, PDBe:7t92, PDBj:7t92
PDBsum7t92
PubMed35768507
UniProtG2Q1C9|PEX2_THET4 Peroxisome assembly protein 2 (Gene Name=PEX2)

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