Structure of PDB 7t7m Chain A Binding Site BS02

Receptor Information

>7t7m Chain A (length=260) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]

VERIVSRDIARGYERIPIPCVNAVDSEPCPSNYKYVSQNCVTSPMNIDRN
ITHLQYCVCIDDCSSSNCMCGQLSMRCWYDKDGRLLPEFNMAEPPLIFEC
NHACSCWRNCRNRVVQNGLRARLQLYRTRDMGWGVRSLQDIPPGTFVCEY
VGELISDSEADVREEDSYLFDLDNKGEVYCIDARFYGNVSRFINHHCEPN
LVPVRVFMAHQDLRFPRIAFFSTRLIEAGEQLGFDYGERFWDIKGKLFSC
RCGSPKCRHS

Ligand information

Ligand ID

InChI

InChI=1S/Zn/q+2

InChIKey

PTFCDOFLOPIGGS-UHFFFAOYSA-N

SMILES

Software	SMILES
CACTVS 3.341	[Zn++]
ACDLabs 10.04 OpenEye OEToolkits 1.5.0	[Zn+2]

Formula

Name

ZINC ION

PDB chain

7t7m Chain A Residue 1302 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]

Receptor-Ligand Complex Structure

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Structure summary

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PDB	7t7m Discovery of the First-in-Class G9a/GLP Covalent Inhibitors.
Resolution	2.85 Å
Binding residue (original residue number in PDB)	C1068 C1105 C1111 C1115
Binding residue (residue number reindexed from 1)	C63 C100 C106 C110
Annotation score	1

Enzymatic activity

Enzyme Commision number

2.1.1.-
2.1.1.367: [histone H3]-lysine(9) N-methyltransferase.

Gene Ontology

	Molecular Function
GO:0002039	p53 binding
GO:0008270	zinc ion binding
GO:0016279	protein-lysine N-methyltransferase activity
GO:0042054	histone methyltransferase activity
GO:0046974	histone H3K9 methyltransferase activity

	Cellular Component
GO:0005634	nucleus

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Molecular Function

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Cellular Component

External links

PDB	RCSB:7t7m, PDBe:7t7m, PDBj:7t7m
PDBsum	7t7m
PubMed	35763668
UniProt	Q9H9B1\|EHMT1_HUMAN Histone-lysine N-methyltransferase EHMT1 (Gene Name=EHMT1)

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