Structure of PDB 7sz8 Chain A Binding Site BS02

Receptor Information
>7sz8 Chain A (length=420) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
VNDNEPIFVSSPFQATVLENVPLGYPVVHIQAVDADSGENARLHYRLVDT
PTPDFPFQIHNSSGWITVCAELDREEVEHYSFGVEAVDHGSPPMSSSTSV
SITVLDVNDNDPVFTQPTYELRLNEDAAVGSSVLTLQARDRDANSVITYQ
LTGGNTRNRFALSSQRGGGLITLALPLDYKQEQQYVLAVTASDGTRSHTA
HVLINVTDANTHRPVFQSSHYTVSVSEDRPVGTSIATLSANDEDTGENAR
ITYVIQDPVPQFRIDPDSGTMYTMMELDYENQVAYTLTIMAQDNGIPQKS
DTTTLEILILDANDNAPQFLWDFYQGSIFEDAPPSTSILQVSATDRDSGP
NGRLLYTFQGGDDGDGDFYIEPTSGVIRTQRRLDRENVAVYNLWALAVDR
GSPTPLSASVEIQVTILDIN
Ligand information
Ligand IDCA
InChIInChI=1S/Ca/q+2
InChIKeyBHPQYMZQTOCNFJ-UHFFFAOYSA-N
SMILES
SoftwareSMILES
CACTVS 3.341[Ca++]
ACDLabs 10.04
OpenEye OEToolkits 1.5.0		[Ca+2]
FormulaCa
NameCALCIUM ION
ChEMBL
DrugBankDB14577
ZINC
PDB chain7sz8 Chain A Residue 802 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
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PDB7sz8 Crystal structure of human CELSR1 EC4-7
Resolution2.337 Å
Binding residue
(original residue number in PDB)		E341 E413 D444 V445 D447 D480
Binding residue
(residue number reindexed from 1)		E19 E75 D106 V107 D109 D142
Annotation score4
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0005509 calcium ion binding
Biological Process
GO:0007155 cell adhesion
GO:0007156 homophilic cell adhesion via plasma membrane adhesion molecules
GO:0098609 cell-cell adhesion
Cellular Component
GO:0005886 plasma membrane
GO:0016020 membrane

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:7sz8, PDBe:7sz8, PDBj:7sz8
PDBsum7sz8
PubMed
UniProtQ9NYQ6|CELR1_HUMAN Cadherin EGF LAG seven-pass G-type receptor 1 (Gene Name=CELSR1)

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