Structure of PDB 7syr Chain A Binding Site BS02

Receptor Information

>7syr Chain A (length=99) Species: 9606 (Homo sapiens)

RELVFKEDGQEYAQVIKMLGNGRLEAMCFDGVKRLCHIRGKLRKKVWINT
SDIILVGLRDYQDNKADVILKYNADEARSLKAYGELPEHAKINETDTFG

Ligand information

>7syr Chain z (length=188)

cccccccucccgggagagccauaguggucugcggaaccggugaguacacc
ggaaugauuugggcgugcccccgcaagacugcuagccgaguaguguuggg
ucgcgaaaggccuugugguacugccugauagggugcuugcgagugccccg
ggaggucucguagaccgugcaccaugagcacgaauccu

.....<<<<<<<<<<<.<<<<<<<<<<<<<<<<<..<<<<<<....>>>>
>><<<.>>>.<<<<..>>>>>>>>>.>>>>>>>><<<.....<<......
..>>....>>>....>>>>.>><<<<....>>>><<...((((.>>>>>>
>>>>>.))))............................

Receptor-Ligand Complex Structure

Structure summary

• PDB: 7syr Molecular architecture of 40S translation initiation complexes on the hepatitis C virus IRES.
• Resolution: 3.6 Å
• Binding residue (original residue number in PDB): K67 W70
• Binding residue (residue number reindexed from 1): K44 W47

Gene Ontology

Molecular Function

• GO:0000049 tRNA binding
• GO:0003723 RNA binding
• GO:0003743 translation initiation factor activity
• GO:0005515 protein binding
• GO:0008135 translation factor activity, RNA binding

Biological Process

• GO:0006412 translation
• GO:0006413 translational initiation
• GO:0042255 ribosome assembly

Cellular Component

• GO:0005737 cytoplasm
• GO:0005829 cytosol
• GO:0016282 eukaryotic 43S preinitiation complex
• GO:0033290 eukaryotic 48S preinitiation complex
• GO:0043614 multi-eIF complex

External links

• PDB: RCSB:7syr, PDBe:7syr, PDBj:7syr
• PDBsum: 7syr
• PubMed: 35822879
• UniProt: P47813|IF1AX_HUMAN Eukaryotic translation initiation factor 1A, X-chromosomal (Gene Name=EIF1AX)