Structure of PDB 7sr6 Chain A Binding Site BS02

Receptor Information
>7sr6 Chain A (length=566) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
KPIPLTWKTEKPVWVNQWPLPKQKLEALHLLANEQLEKGHIEPSFSPWNS
PVFVIQKKSGKWRMLTDLRAVNALIQPMGPLQPGLPSPAMIPKDWPLIII
DLKDCFFTIPLAEQDCEKFAFTIPAINNKEPATRFQWKVLPQGMLNSPTI
CQTFVGRALQPVREKFSDCYIIHYIDDILCAAETKDKLIDCYTFLQAEVA
NAGLAIASDKIQTSTPFHYLGMQIENRKIKPQKIEIRKDTLKTLNDFQKL
LGDINWIRPTLGIPTYAMSNLFSILRGDSDLNSKRILTPEATKEIKLVEE
KIQSAQINRIGPLAPLQLLIFATAHSPTGIIIQNTDLVEWSFLPHSTVKT
FTLYLDQIATLIGQTRLRITKLCGNDPDKIVVPLTKEQVRQAFINSGAWQ
IGLANFVGIIDNHYPKTKIFQFLKLTTWILPKITRCEPLENALTVFTDGS
SNGKAAYTGPKERVIKTPYQSAQRAELVAVITVLQDFDQPINIISDSAYV
VQATRDVETALIKYSMDDQLNQLFNLLQQTVRKRNFPFYITHIRAHTNLP
GPLTKANEQADLLVSS
Ligand information
Receptor-Ligand Complex Structure
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PDB7sr6 Human endogenous retrovirus-K (HERV-K) reverse transcriptase (RT) structure and biochemistry reveals remarkable similarities to HIV-1 RT and opportunities for HERV-K-specific inhibition.
Resolution2.62 Å
Binding residue
(original residue number in PDB)		Y194 I195 D197 L240 R257 N265 Q268 G272 D273 W276 K369 T370 Y519
Binding residue
(residue number reindexed from 1)		Y174 I175 D177 L220 R237 N245 Q248 G252 D253 W256 K349 T350 Y499
Enzymatic activity
Enzyme Commision number 2.7.7.49: RNA-directed DNA polymerase.
3.1.26.4: ribonuclease H.
Gene Ontology
Molecular Function
GO:0003676 nucleic acid binding
GO:0003964 RNA-directed DNA polymerase activity
GO:0004523 RNA-DNA hybrid ribonuclease activity
Biological Process
GO:0006278 RNA-templated DNA biosynthetic process

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Molecular Function
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Biological Process
External links
PDB RCSB:7sr6, PDBe:7sr6, PDBj:7sr6
PDBsum7sr6
PubMed35771941
UniProtQ9UQG0|POK11_HUMAN Endogenous retrovirus group K member 11 Pol protein (Gene Name=ERVK-11)

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