Structure of PDB 7sl4 Chain A Binding Site BS02

Receptor Information
>7sl4 Chain A (length=786) Species: 10090 (Mus musculus) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
YPGEVCPGMDIRNNLTRLHELENCSVIEGHLQILLMFKTRPEDFRDLSFP
KLIMITDYLLLFRVYGLESLKDLFPNLTVIRGSRLFFNYALVIFEMVHLK
ELGLYNLMNITRGSVRIEKNNELCYLATIDWSRILDSVEDNYIVLNKDNC
PATFVERCWTHSHCQKVCPTICKSHGCTAEGLCCHKECLGNCSEPDDPTK
CVACRNFYLDGQCVETCPPPYYHFQDWRCVNFSFCQDLHFKCRNSRCHQY
VIHNNKCIPECPSGYTMNSSNLMCTPCLGPCPKVCQIGEKTIDSVTSAQE
LRGCTVINGSLIINIRGAAELEANLGLIEEISGFLKIRRSYALVSLSFFR
KLHLIRGETLEIGNYSFYALDNQNLRQLWDWSKHNLTITQGKLFFHYNPK
LCLSEIHKMEEVSGTKGRQERNDIALKTNGDQASCENELLKFSFIRTSFD
KILLRWEPYWPPDFRDLLGFMLFYKEAPYQNVTEFSNSWTVVDIDPPQRS
HPGWLMRGLKPWTQYAIFVKTLVTFSDERRTYGAKSDIIYVQTDATNPSV
PLDPISVSNSSSQIILKWKPPSDPNGNITHYLVYWERQAEDSELFELDYC
LKGLKLPSRQILKELEESSFRKTFEDYLHNVVFVPRHRPFEKVVNKESLV
ISGLRHFTGYRIELQACNQDSPDERCSVAAYVSARTMPEAKADDIVGPVT
HEIFENNVVHLMWQEPKEPNGLIVLYEVSYRRYGDEELHLCVSRKHFALE
RGCRLRGLSPGNYSVRVRATSLAGNGSWTEPTYFYV
Ligand information
>7sl4 Chain D (length=21) Species: 9606 (Homo sapiens) [Search peptide sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
CGSHLVEALYRVCGERGFFYT
Receptor-Ligand Complex Structure
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PDB7sl4 Synergistic activation of the insulin receptor via two distinct sites.
Resolution5.0 Å
Binding residue
(original residue number in PDB)		N15 L37 F39 K40 R65
Binding residue
(residue number reindexed from 1)		N13 L35 F37 K38 R63
Enzymatic activity
Enzyme Commision number 2.7.10.1: receptor protein-tyrosine kinase.
Gene Ontology
Molecular Function
GO:0004672 protein kinase activity
GO:0004713 protein tyrosine kinase activity
GO:0004714 transmembrane receptor protein tyrosine kinase activity
GO:0005524 ATP binding
GO:0043548 phosphatidylinositol 3-kinase binding
GO:0043560 insulin receptor substrate binding
Biological Process
GO:0006468 protein phosphorylation
GO:0007169 cell surface receptor protein tyrosine kinase signaling pathway
GO:0046777 protein autophosphorylation
Cellular Component
GO:0016020 membrane

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:7sl4, PDBe:7sl4, PDBj:7sl4
PDBsum7sl4
PubMed35361965
UniProtP15208|INSR_MOUSE Insulin receptor (Gene Name=Insr)

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