Structure of PDB 7sl3 Chain A Binding Site BS02

Receptor Information
>7sl3 Chain A (length=820) Species: 10090 (Mus musculus) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
HLYPGEVCPGMDIRNNLTRLHELENCSVIEGHLQILLMFKTRPEDFRDLS
FPKLIMITDYLLLFRVYGLESLKDLFPNLTVIRGSRLFFNYALVIFEMVH
LKELGLYNLMNITRGSVRIEKNNELCYLATIDWSRILDSVEDNYIVLNKD
DNEECGDVCPGTNCPATVINGQFVERCWTHSHCQKVCPTICKSHGCTAEG
LCCHKECLGNCSEPDDPTKCVACRNFYLDGQCVETCPPPYYHFQDWRCVN
FSFCQDLHFKCRNSRCHQYVIHNNKCIPECPSGYTMNSSNLMCTPCLGPC
PKVCQILEGEKTIDSVTSAQELRGCTVINGSLIINIRGGNNLAAELEANL
GLIEEISGFLKIRRSYALVSLSFFRKLHLIRGETLEIGNYSFYALDNQNL
RQLWDWSKHNLTITQGKLFFHYNPKLCLSEIHKMEEVSGTKGRQERNDIA
LKTNGDQASCENELLKFSFIRTSFDKILLRWEPYWPPDFRDLLGFMLFYK
EAPYQNVTEFSWTVVDIDPPQRSHPGWLMRGLKPWTQYAIFVKTLVTFSD
ERRTYGAKSDIIYVQTDATNPSVPLDPISVSNSSSQIILKWKPPSDPNGN
ITHYLVYWERQAEDSELFELDYCLKGLKLPSRSCPKTDSQILKELEESSF
RKTFEDYLHNVVFVPRPHRPFEKVVNKESLVISGLRHFTGYRIELQACNQ
DSPDERCSVAAYVSARTMPEAKADDIVGPVTHEIFENNVVHLMWQEPKEP
NGLIVLYEVSYRRYGDEELHLCVSRKHFALERGCRLRGLSPGNYSVRVRA
TSLAGNGSWTEPTYFYVTDY
Ligand information
>7sl3 Chain D (length=27) Species: 9606 (Homo sapiens) [Search peptide sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
VNQHLCGSHLVEALYLVCGERGFFYTP
Receptor-Ligand Complex Structure
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PDB7sl3 Synergistic activation of the insulin receptor via two distinct sites.
Resolution3.4 Å
Binding residue
(original residue number in PDB)		P495 D496 F497 R498 R539 H712 F716 V717 R719
Binding residue
(residue number reindexed from 1)		P487 D488 F489 R490 R522 H659 F663 V664 R666
Enzymatic activity
Enzyme Commision number 2.7.10.1: receptor protein-tyrosine kinase.
Gene Ontology
Molecular Function
GO:0004672 protein kinase activity
GO:0004713 protein tyrosine kinase activity
GO:0004714 transmembrane receptor protein tyrosine kinase activity
GO:0005524 ATP binding
GO:0043548 phosphatidylinositol 3-kinase binding
GO:0043560 insulin receptor substrate binding
Biological Process
GO:0006468 protein phosphorylation
GO:0007169 cell surface receptor protein tyrosine kinase signaling pathway
GO:0046777 protein autophosphorylation
Cellular Component
GO:0016020 membrane

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:7sl3, PDBe:7sl3, PDBj:7sl3
PDBsum7sl3
PubMed35361965
UniProtP15208|INSR_MOUSE Insulin receptor (Gene Name=Insr)

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