Structure of PDB 7sl2 Chain A Binding Site BS02

Receptor Information
>7sl2 Chain A (length=806) Species: 10090 (Mus musculus) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
YPGEVCPGMDIRNNLTRLHELENCSVIEGHLQILLMFKTRPEDFRDLSFP
KLIMITDYLLLFRVYGLESLKDLFPNLTVIRGSRLFFNYALVIFEMVHLK
ELGLYNLMNITRGSVRIEKNNELCYLATIDWSRILDSVEDNYIVLNKDDN
EECGDVCPGTNCPATVINGQFVERCWTHSHCQKVCPTICKSHGCTAEGLC
CHKECLGNCSEPDDPTKCVACRNFYLDGQCVETCPPPYYHFQDWRCVNFS
FCQDLHFKCRNSRCHQYVIHNNKCIPECPSGYTMNSSNLMCTPCLGPCPK
VCQIGEKTIDSVTSAQELRGCTVINGSLIINIRGAAELEANLGLIEEISG
FLKIRRSYALVSLSFFRKLHLIRGETLEIGNYSFYALDNQNLRQLWDWSK
HNLTITQGKLFFHYNPKLCLSEIHKMEEVSGTKGRQERNDIALKTNGDQA
SCENELLKFSFIRTSFDKILLRWEPYWPPDFRDLLGFMLFYKEAPYQNVT
EFDGQSNSWTVVDIDPPQRSHPGWLMRGLKPWTQYAIFVKTLVTFSDERR
TYGAKSDIIYVQTDATNPSVPLDPISVSNSSSQIILKWKPPSDPNGNITH
YLVYWERQAEDSELFELDYCLKGLKLPSRQILKELEESSFRKTFEDYLHN
VVFVPRHRPFEKVVNKESLVISGLRHFTGYRIELQACNQDSPDERCSVAA
YVSARTMPEAKADDIVGPVTHEIFENNVVHLMWQEPKEPNGLIVLYEVSY
RRYGDEELHLCVSRKHFALERGCRLRGLSPGNYSVRVRATSLAGNGSWTE
PTYFYV
Ligand information
>7sl2 Chain D (length=25) Species: 9606 (Homo sapiens) [Search peptide sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
QHLCGSHLVEALYLVCGERGFFYTP
Receptor-Ligand Complex Structure
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PDB7sl2 Synergistic activation of the insulin receptor via two distinct sites.
Resolution3.6 Å
Binding residue
(original residue number in PDB)		D12 R14 N15 L37 F39 K40 R65 E97
Binding residue
(residue number reindexed from 1)		D10 R12 N13 L35 F37 K38 R63 E95
Enzymatic activity
Enzyme Commision number 2.7.10.1: receptor protein-tyrosine kinase.
Gene Ontology
Molecular Function
GO:0004672 protein kinase activity
GO:0004713 protein tyrosine kinase activity
GO:0004714 transmembrane receptor protein tyrosine kinase activity
GO:0005524 ATP binding
GO:0043548 phosphatidylinositol 3-kinase binding
GO:0043560 insulin receptor substrate binding
Biological Process
GO:0006468 protein phosphorylation
GO:0007169 cell surface receptor protein tyrosine kinase signaling pathway
GO:0046777 protein autophosphorylation
Cellular Component
GO:0016020 membrane

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:7sl2, PDBe:7sl2, PDBj:7sl2
PDBsum7sl2
PubMed35361965
UniProtP15208|INSR_MOUSE Insulin receptor (Gene Name=Insr)

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