Structure of PDB 7skr Chain A Binding Site BS02

Receptor Information
>7skr Chain A (length=314) Species: 347537 (Bat SARS CoV Rf1/2004) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
EVKTIKVFTTVDNTNLHTQLVDMSMTYGQHFGPTYLDGADVTKVKPHVNH
EGKTFFVLPSDDTLRSEAFEYYHTLDESFLGRYMSALNHTKKWKFPQVGG
LTSIKWADNNCYLSSVLLALQQIEVKFNAPALQEAYYRARAGDAANFCAL
ILAYSNKTVGELGDVRETMTHLLQHANLESAKRVLNLVCKHCGQKTTTLM
GVEAVMYMGTLSYDELKAGVSIPCVCGRDATQYLVQQESSFVMMSAPPAE
YKLQQGTFLCANEYTGNYQCGHYTHITAKETLYRIDGAHLTKMSEYKGPV
TDVFYKETSYTTTI
Ligand information
Ligand IDZN
InChIInChI=1S/Zn/q+2
InChIKeyPTFCDOFLOPIGGS-UHFFFAOYSA-N
SMILES
SoftwareSMILES
CACTVS 3.341[Zn++]
ACDLabs 10.04
OpenEye OEToolkits 1.5.0		[Zn+2]
FormulaZn
NameZINC ION
ChEMBLCHEMBL1236970
DrugBankDB14532
ZINC
PDB chain7skr Chain A Residue 403 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
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PDB7skr Exploring Noncovalent Protease Inhibitors for the Treatment of Severe Acute Respiratory Syndrome and Severe Acute Respiratory Syndrome-Like Coronaviruses.
Resolution2.89 Å
Binding residue
(original residue number in PDB)		C190 C193 C225 C227
Binding residue
(residue number reindexed from 1)		C189 C192 C224 C226
Annotation score4
Enzymatic activity
Enzyme Commision number 3.4.19.12: ubiquitinyl hydrolase 1.
Gene Ontology
Molecular Function
GO:0008234 cysteine-type peptidase activity
Biological Process
GO:0006508 proteolysis

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Molecular Function
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Biological Process
External links
PDB RCSB:7skr, PDBe:7skr, PDBj:7skr
PDBsum7skr
PubMed35199517
UniProtQ0QDZ2

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