Structure of PDB 7sfg Chain A Binding Site BS02

Receptor Information
>7sfg Chain A (length=817) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
RISWVGEAVKTDGKKSYYKKVCIDAETLEVGDCVSVIPDDSSKPLYLARV
TALWEDSSNGQMFHAHWFCAGTDTVLGATSDPLELFLVDECEDMQLSYIH
SKVKVIYKAPSENWAMEGGMDKTYFYQLWYDQDYARFESPPKTQPNKFKF
CVSCARLAEMRQKEIPRVLEQLEDLDSRVLYYSATKNGILYRVGDGVYLP
PEAFTFNIKPVDEDLYPEHYRKYSDYIKGSNLDAPEPYRIGRIKEIFCPK
KSNGRPNETDIKIRVNKFYRPENTHKSTPASYHADINLLYWSDEEAVVDF
KAVQGRCTVEYGEDLPECVQVYSMGGPNRFYFLEAYNAKSKSFEDPPNHA
RKLPKLRTLDVFSGCGGLSEGFHQAGISDTLWAIEMWDPAAQAFRLNNPG
STVFTEDCNILLKLVMAGETTNSRGQRLPQKGDVEMLCGGPPCQGFSGMN
RFNSRTYSKFKNSLVVSFLSYCDYYRPRFFLLENVRNFVSFKRSMVLKLT
LRCLVRMGYQCTFGVLQAGQYGVAQTRRRAIILAAAPGEKLPLFPEPLHV
FAPRACQLSVVVDDKKFVSNITRLSSGPFRTITVRDTMSDLPEVRNGASA
LEISYNGEPQSWFQRQLRGAQYQPILRDHICKDMSALVAARMRHIPLAPG
SDWRDLPNIEVRLSDGTMARKLRYTHHDRKNGRSSSGALRGVCSCVEAGK
ACDPAARQFNTLIPWCLPHTGNRHNHWAGLYGRLEWDGFFSTTVTNPEPM
GKQGRVLHPEQHRVVSVRECARSQGFPDTYRLFGNILDKHRQVGNAVPPP
LAKAIGLEIKLCMLAKA
Ligand information
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB7sfg Structural characterization of dicyanopyridine containing DNMT1-selective, non-nucleoside inhibitors.
Resolution2.43 Å
Binding residue
(original residue number in PDB)		Y976 S977 Y979 K981 C1226 Q1227 S1230 G1231 M1232 N1233 R1234 F1235 E1266 V1268 R1311 R1312 N1508 V1527 T1528 G1534 K1535 Q1536 G1577
Binding residue
(residue number reindexed from 1)		Y223 S224 Y226 K228 C443 Q444 S447 G448 M449 N450 R451 F452 E483 V485 R528 R529 N725 V744 T745 G751 K752 Q753 G794
Enzymatic activity
Enzyme Commision number 2.1.1.37: DNA (cytosine-5-)-methyltransferase.
Gene Ontology
Molecular Function
GO:0003682 chromatin binding
GO:0008168 methyltransferase activity

View graph for
Molecular Function
External links
PDB RCSB:7sfg, PDBe:7sfg, PDBj:7sfg
PDBsum7sfg
PubMed35395178
UniProtP26358|DNMT1_HUMAN DNA (cytosine-5)-methyltransferase 1 (Gene Name=DNMT1)

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