Structure of PDB 7s6h Chain A Binding Site BS02

Receptor Information
>7s6h Chain A (length=223) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
DKLYRVEYAKSGRASCKKCSESIPKDSLRMAIMVQSPMFDGKVPHWYHFS
CFWKVGHSIRHPDVEVDGFSELRWDDQQKVKKTAEAKSKKEKDKDSKLEK
ALKAQNDLIWNIKDELKKVCSTNDLKELLIFNKQQVPSGESAILDRVADG
MVFGALLPCEECSGQLVFKSDAYYCTGDVTAWTKCMVKTQTPNRKEWVTP
KEFREISYLKKLKVKKQDRIFPP
Ligand information
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB7s6h Captured snapshots of PARP1 in the active state reveal the mechanics of PARP1 allostery.
Resolution3.1 Å
Binding residue
(original residue number in PDB)		E263 I266 F267 P336 E338
Binding residue
(residue number reindexed from 1)		E127 I130 F131 P200 E202
Enzymatic activity
Enzyme Commision number 2.4.2.-
2.4.2.30: NAD(+) ADP-ribosyltransferase.
Gene Ontology
Molecular Function
GO:0003677 DNA binding
GO:0008270 zinc ion binding

View graph for
Molecular Function
External links
PDB RCSB:7s6h, PDBe:7s6h, PDBj:7s6h
PDBsum7s6h
PubMed35793673
UniProtP09874|PARP1_HUMAN Poly [ADP-ribose] polymerase 1 (Gene Name=PARP1)

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