Structure of PDB 7s68 Chain A Binding Site BS02

Receptor Information
>7s68 Chain A (length=223) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
SDKLYRVEYAKSGRASCKKCSESIPKDSLRMAIMVQSPMFDGKVPHWYHF
SCFWKVGHSIRHPDVEVDGFSELRWDDQQKVKKTAEASKKEKDKDSKLEK
ALKAQNDLIWNIKDELKKVCSTNDLKELLIFNKQQVPSGESAILDRVADG
MVFGALLPCEECSGQLVFKSDAYYCTGDVTAWTKCMVKTQTPNRKEWVTP
KEFREISYLKKLKVKKQDRIFPP
Ligand information
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB7s68 Captured snapshots of PARP1 in the active state reveal the mechanics of PARP1 allostery.
Resolution3.3 Å
Binding residue
(original residue number in PDB)		S16 R18 A19 S20 K22 R34 S274 G275
Binding residue
(residue number reindexed from 1)		S12 R14 A15 S16 K18 R30 S138 G139
Enzymatic activity
Enzyme Commision number 2.4.2.-
2.4.2.30: NAD(+) ADP-ribosyltransferase.
Gene Ontology
Molecular Function
GO:0003677 DNA binding
GO:0008270 zinc ion binding

View graph for
Molecular Function
External links
PDB RCSB:7s68, PDBe:7s68, PDBj:7s68
PDBsum7s68
PubMed35793673
UniProtP09874|PARP1_HUMAN Poly [ADP-ribose] polymerase 1 (Gene Name=PARP1)

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