Structure of PDB 7s3f Chain A Binding Site BS02

Receptor Information
>7s3f Chain A (length=409) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
MNNFEEFDCHFLDEGFTAKDILDQKINEVSSSDDKDAFYVADLGDILKKH
LRWLKALPRVTPFYAVKCNDSKAIVKTLAATGTGFDCASKTEIQLVQSLG
VPPERIIYANPCKQVSQIKYAANNGVQMMTFDSEVELMKVARAHPKAKLV
LRIATDDSKAVCRLSVKFGATLRTSRLLLERAKELNIDVVGVSFHVGSGC
TDPETFVQAISDARCVFDMGAEVGFSMYLLDIGGGFPGSEDVKLKFEEIT
GVINPALDKYFPSDSGVRIIAEPGRYYVASAFTLAVNIIAKKIVLKSEQT
FMYYVNDGVYGSFNCILYDHAHVKPLLQKRPKPDEKYYSSSIWGPTCDGL
DRIVERCDLPEMHVGDWMLFENMGAYTVAAASTFNGFQRPTIYYVMSGPA
WQLMQQFQN
Ligand information
Ligand IDXAP
InChIInChI=1S/C3H10N2O/c4-2-1-3-6-5/h1-5H2
InChIKeyVSZFWDPIWSPZON-UHFFFAOYSA-N
SMILES
SoftwareSMILES
CACTVS 3.341NCCCON
ACDLabs 10.04O(N)CCCN
OpenEye OEToolkits 1.5.0C(CN)CON
FormulaC3 H10 N2 O
Name3-AMINOOXY-1-AMINOPROPANE
ChEMBLCHEMBL281021
DrugBank
ZINC
PDB chain7s3f Chain A Residue 502 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
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PDB7s3f Structural basis of binding and inhibition of ornithine decarboxylase by 1-amino-oxy-3-aminopropane.
Resolution2.49 Å
Binding residue
(original residue number in PDB)		L166 D332
Binding residue
(residue number reindexed from 1)		L164 D319
Annotation score2
Enzymatic activity
Enzyme Commision number 4.1.1.17: ornithine decarboxylase.
Gene Ontology
Molecular Function
GO:0003824 catalytic activity
GO:0004586 ornithine decarboxylase activity
GO:0005515 protein binding
GO:0016831 carboxy-lyase activity
GO:0042803 protein homodimerization activity
Biological Process
GO:0001822 kidney development
GO:0006595 polyamine metabolic process
GO:0006596 polyamine biosynthetic process
GO:0008283 cell population proliferation
GO:0008284 positive regulation of cell population proliferation
GO:0009615 response to virus
GO:0033387 putrescine biosynthetic process from ornithine
GO:0042176 regulation of protein catabolic process
Cellular Component
GO:0005575 cellular_component
GO:0005737 cytoplasm
GO:0005829 cytosol

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:7s3f, PDBe:7s3f, PDBj:7s3f
PDBsum7s3f
PubMed34796899
UniProtP11926|DCOR_HUMAN Ornithine decarboxylase (Gene Name=ODC1)

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